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Gene Review

UL49.5  -  type 1 membrane protein; contains a signal...

Suid herpesvirus 1

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Disease relevance of UL49.5


High impact information on UL49.5

  • In the alphaherpesvirus pseudorabies virus (PrV), the UL49.5 product is an O-glycosylated structural protein of the viral envelope, glycoprotein N (gN) (A. Jöns, H. Granzow, R. Kuchling, and T. C. Mettenleiter, J. Virol. 70:1237-1241, 1996) [3].
  • Genes homologous to the herpes simplex virus UL49.5 open reading frame are conserved throughout the Herpesviridae [3].
  • The protein expressed by this virus confirmed that the first methionine codon of UL49.5 served as the initiating codon [4].

Biological context of UL49.5


Analytical, diagnostic and therapeutic context of UL49.5


  1. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. Jöns, A., Granzow, H., Kuchling, R., Mettenleiter, T.C. J. Virol. (1996) [Pubmed]
  2. Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Koppers-Lalic, D., Reits, E.A., Ressing, M.E., Lipinska, A.D., Abele, R., Koch, J., Marcondes Rezende, M., Admiraal, P., van Leeuwen, D., Bienkowska-Szewczyk, K., Mettenleiter, T.C., Rijsewijk, F.A., Tampé, R., Neefjes, J., Wiertz, E.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Glycoproteins M and N of pseudorabies virus form a disulfide-linked complex. Jöns, A., Dijkstra, J.M., Mettenleiter, T.C. J. Virol. (1998) [Pubmed]
  4. The unique sequence of the herpes simplex virus 1 L component contains an additional translated open reading frame designated UL49.5. Barker, D.E., Roizman, B. J. Virol. (1992) [Pubmed]
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