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MeSH Review:

Herpesvirus 1, Suid

Ober, B.T. et al., Ramos-Kuri, M. et al., Koppers-Lalic, D. et al., Mettenleiter, T.C. et al.

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Disease relevance of Herpesvirus 1, Suid

UL49.5 homologs encoded by two other varicelloviruses, pseudorabies-virus and equine herpesvirus 1, also block TAP [1].
Glycoprotein gIII is one of the major envelope glycoproteins of pseudorabies virus (PrV) (Suid herpesvirus 1) [2].

High impact information on Herpesvirus 1, Suid

High titers of virus-neutralizing antibodies directed against glycoprotein gC of Pseudorabies virus (PRV) (Suid herpesvirus 1) are generally observed in the serum of immunized pigs [3].
The possible antiherpetic effect of three polyanions (heparin, chondroitin sulfate and dextran sulfate), as well as one polycation (protamine sulfate) was tested in vitro and in vivo against pseudorabies virus (Suid herpesvirus 1) [4].

References

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Koppers-Lalic, D., Reits, E.A., Ressing, M.E., Lipinska, A.D., Abele, R., Koch, J., Marcondes Rezende, M., Admiraal, P., van Leeuwen, D., Bienkowska-Szewczyk, K., Mettenleiter, T.C., Rijsewijk, F.A., Tampé, R., Neefjes, J., Wiertz, E.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Interaction of glycoprotein gIII with a cellular heparinlike substance mediates adsorption of pseudorabies virus. Mettenleiter, T.C., Zsak, L., Zuckermann, F., Sugg, N., Kern, H., Ben-Porat, T. J. Virol. (1990) [Pubmed]
The porcine humoral immune response against pseudorabies virus specifically targets attachment sites on glycoprotein gC. Ober, B.T., Teufel, B., Wiesmüller, K.H., Jung, G., Pfaff, E., Saalmüller, A., Rziha, H.J. J. Virol. (2000) [Pubmed]
In vitro and in vivo effect of heparin, chondroitin, dextran and protamine on the virulence of pseudorabies virus (Suid herpesvirus 1). Ramos-Kuri, M., Kretschmer, R.R., Espinosa-Larios, E.L., Aguilar-Setién, A. Archivos de investigación médica. (1990) [Pubmed]

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