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Gene Review

Homer2  -  homer homolog 2 (Drosophila)

Rattus norvegicus

Synonyms: Cupidin, Homer protein homolog 2, Homer-2, VASP/Ena-related gene up-regulated during seizure and LTP 2, Vesl-2, ...
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High impact information on Homer2

  • Here we report additional members of the Vesl/Homer family of proteins, Vesl-1L and Vesl-2 [1].
  • Vesl-2 (354 amino acids) was highly related to Vesl-1L in that both contain EVH1- and PDZ-like domains at the N terminus (86% conservation) and an MCC (mutated in colorectal cancer)-like domain and a leucine zipper at the C terminus [1].
  • BDNF regulates the translation of Homer2 locally in the synaptodendritic compartment by activating translational initiation via a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway [2].
  • In mature neurons, many of these mRNAs encode proteins that are known to function at synapses, including CamKIIalpha, NMDA receptor subunits, and the postsynaptic density (PSD) scaffolding protein Homer2 [2].
  • The local translation of the cytoskeleton-associated protein Homer2 in particular might have important implications for growth cone dynamics and dendritic spine development [2].


  1. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H., Inokuchi, K. J. Biol. Chem. (1998) [Pubmed]
  2. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. Schratt, G.M., Nigh, E.A., Chen, W.G., Hu, L., Greenberg, M.E. J. Neurosci. (2004) [Pubmed]
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