High impact information on homer

• Our data suggest that two processes, one requiring Bifocal and an intact F-actin cytoskeleton and a second requiring Homer but independent of intact F-actin, may act redundantly to mediate posterior anchoring of the osk gene products [1].
• The construction of cosmid libraries of eukaryotic DNA using the Homer series of vectors [2].
• The Homer element contains a long open reading frame (ORF) that encodes a putative transposase [3].
• The Homer element is 3789 bp in size and contains 12-bp imperfect inverted terminal repeats [3].
• In addition to the initial reports of Vesl/Homer protein expression in the central nervous system, members of this protein family have now been identified in other excitable cells in various muscle types and in a large number of nonexcitable cells [4].

Anatomical context of homer

• Our results argue that in the CNS, Homer-related proteins operate in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity [5].
• Similarly to its mammalian counterpart, the Drosophila Homer localizes to the dendrites and the endoplasmic reticulum (ER) [5].

Other interactions of homer

• This subcellular distribution is dependent on an intact Enabled/Vasp homology 1 domain, suggesting that Homer must bind to one or more of its partners for proper localization [5].

References