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Gene Review

homer  -  CG11324 gene product from transcript...

Drosophila melanogaster

Synonyms: BEST:LD03829, CG11324, Dhom, Dhomer, Dm Homer, ...
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High impact information on homer

  • Our data suggest that two processes, one requiring Bifocal and an intact F-actin cytoskeleton and a second requiring Homer but independent of intact F-actin, may act redundantly to mediate posterior anchoring of the osk gene products [1].
  • The construction of cosmid libraries of eukaryotic DNA using the Homer series of vectors [2].
  • The Homer element contains a long open reading frame (ORF) that encodes a putative transposase [3].
  • The Homer element is 3789 bp in size and contains 12-bp imperfect inverted terminal repeats [3].
  • In addition to the initial reports of Vesl/Homer protein expression in the central nervous system, members of this protein family have now been identified in other excitable cells in various muscle types and in a large number of nonexcitable cells [4].

Anatomical context of homer

  • Our results argue that in the CNS, Homer-related proteins operate in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity [5].
  • Similarly to its mammalian counterpart, the Drosophila Homer localizes to the dendrites and the endoplasmic reticulum (ER) [5].

Other interactions of homer

  • This subcellular distribution is dependent on an intact Enabled/Vasp homology 1 domain, suggesting that Homer must bind to one or more of its partners for proper localization [5].


  1. Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes. Babu, K., Cai, Y., Bahri, S., Yang, X., Chia, W. Genes Dev. (2004) [Pubmed]
  2. The construction of cosmid libraries of eukaryotic DNA using the Homer series of vectors. Chia, W., Scott, M.R., Rigby, P.W. Nucleic Acids Res. (1982) [Pubmed]
  3. The Queensland fruit fly, Bactrocera tryoni, contains multiple members of the hAT family of transposable elements. Pinkerton, A.C., Whyard, S., Mende, H.A., Coates, C.J., O'Brochta, D.A., Atkinson, P.W. Insect Mol. Biol. (1999) [Pubmed]
  4. Effects of Vesl/Homer proteins on intracellular signaling. Duncan, R.S., Hwang, S.Y., Koulen, P. Exp. Biol. Med. (Maywood) (2005) [Pubmed]
  5. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. Diagana, T.T., Thomas, U., Prokopenko, S.N., Xiao, B., Worley, P.F., Thomas, J.B. J. Neurosci. (2002) [Pubmed]
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