Gene Review:
Bdnf - brain-derived neurotrophic factor
Rattus norvegicus
Synonyms:
BDNF, Brain-derived neurotrophic factor
- BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Hyman, C., Hofer, M., Barde, Y.A., Juhasz, M., Yancopoulos, G.D., Squinto, S.P., Lindsay, R.M. Nature (1991)
- Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N.J., Ryan, T.E., Acheson, A., Lindsay, R.M., Persson, H., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. Martin-Iverson, M.T., Todd, K.G., Altar, C.A. J. Neurosci. (1994)
- Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. Jaboin, J., Kim, C.J., Kaplan, D.R., Thiele, C.J. Cancer Res. (2002)
- Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. D'Cruz, B.J., Fertig, K.C., Filiano, A.J., Hicks, S.D., DeFranco, D.B., Callaway, C.W. J. Cereb. Blood Flow Metab. (2002)
- Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease. Pérez-Navarro, E., Canudas, A.M., Akerund, P., Alberch, J., Arenas, E. J. Neurochem. (2000)
- BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. Mousavi, K., Parry, D.J., Jasmin, B.J. Am. J. Physiol., Cell Physiol. (2004)
- Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. Wu, A., Ying, Z., Gomez-Pinilla, F. J. Neurotrauma (2004)
- Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Shirayama, Y., Chen, A.C., Nakagawa, S., Russell, D.S., Duman, R.S. J. Neurosci. (2002)
- trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E., Valenzuela, D.M. Cell (1991)
- BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Guillin, O., Diaz, J., Carroll, P., Griffon, N., Schwartz, J.C., Sokoloff, P. Nature (2001)
- Neurotrophin-evoked rapid excitation through TrkB receptors. Kafitz, K.W., Rose, C.R., Thoenen, H., Konnerth, A. Nature (1999)
- Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Groth, R., Aanonsen, L. Pain (2002)
- Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. Altar, C.A., Boylan, C.B., Fritsche, M., Jones, B.E., Jackson, C., Wiegand, S.J., Lindsay, R.M., Hyman, C. J. Neurochem. (1994)
- Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia. Miyata, K., Omori, N., Uchino, H., Yamaguchi, T., Isshiki, A., Shibasaki, F. Neuroscience (2001)
- Nerve growth factor and brain-derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischaemia and reperfusion. Hiltunen, J.O., Laurikainen, A., Väkevä, A., Meri, S., Saarma, M. J. Pathol. (2001)
- Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo. Neveu, I., Arenas, E. J. Cell Biol. (1996)
- Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus. Muller, D., Djebbara-Hannas, Z., Jourdain, P., Vutskits, L., Durbec, P., Rougon, G., Kiss, J.Z. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Levine, E.S., Dreyfus, C.F., Black, I.B., Plummer, M.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Transcellular induction of neuropeptide Y expression by NT4 and BDNF. Wirth, M.J., Patz, S., Wahle, P. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Schnell, L., Schneider, R., Kolbeck, R., Barde, Y.A., Schwab, M.E. Nature (1994)
- Regulation of cell survival by secreted proneurotrophins. Lee, R., Kermani, P., Teng, K.K., Hempstead, B.L. Science (2001)
- Brain-derived neurotrophic factor regulates expression of androgen receptors in perineal motoneurons. Al-Shamma, H.A., Arnold, A.P. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip, N.Y., Lindsay, R.M. J. Neurosci. (1994)
- Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. Mamounas, L.A., Blue, M.E., Siuciak, J.A., Altar, C.A. J. Neurosci. (1995)
- A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Blanquet, P.R., Mariani, J., Derer, P. Neuroscience (2003)
- Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. Araki, T., Yamada, M., Ohnishi, H., Sano, S., Uetsuki, T., Hatanaka, H. J. Neurochem. (2000)
- The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons. Kimpinski, K., Jelinski, S., Mearow, K. Neuroscience (1999)
- The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes. Xu, B., Michalski, B., Racine, R.J., Fahnestock, M. Neuroscience (2004)
- Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Griesbach, G.S., Hovda, D.A., Molteni, R., Wu, A., Gomez-Pinilla, F. Neuroscience (2004)
- Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain. Törönen, P., Storvik, M., Lindén, A.M., Kontkane, O., Marvanová, M., Lakso, M., Castrén, E., Wong, G. Neurochem. Res. (2002)
- A single brain-derived neurotrophic factor injection modifies hypothalamo-pituitary-adrenocortical axis activity in adult male rats. Givalois, L., Naert, G., Rage, F., Ixart, G., Arancibia, S., Tapia-Arancibia, L. Mol. Cell. Neurosci. (2004)
- Synaptic and extrasynaptic localization of brain-derived neurotrophic factor and the tyrosine kinase B receptor in cultured hippocampal neurons. Swanwick, C.C., Harrison, M.B., Kapur, J. J. Comp. Neurol. (2004)
- Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Li, H., Waites, C.L., Staal, R.G., Dobryy, Y., Park, J., Sulzer, D.L., Edwards, R.H. Neuron (2005)
- Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Leingärtner, A., Heisenberg, C.P., Kolbeck, R., Thoenen, H., Lindholm, D. J. Biol. Chem. (1994)
- Long-term potentiation in the dentate gyrus of the rat hippocampus is accompanied by brain-derived neurotrophic factor-induced activation of TrkB. Gooney, M., Lynch, M.A. J. Neurochem. (2001)
- AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression. Wu, X., Zhu, D., Jiang, X., Okagaki, P., Mearow, K., Zhu, G., McCall, S., Banaudha, K., Lipsky, R.H., Marini, A.M. J. Neurochem. (2004)
- Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. Reibel, S., Vivien-Roels, B., Lê, B.T., Larmet, Y., Carnahan, J., Marescaux, C., Depaulis, A. Eur. J. Neurosci. (2000)
- Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V.M., Persson, H. J. Cell Biol. (1993)
- Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid. Rudge, J.S., Pasnikowski, E.M., Holst, P., Lindsay, R.M. J. Neurosci. (1995)
- Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. Brandoli, C., Sanna, A., De Bernardi, M.A., Follesa, P., Brooker, G., Mocchetti, I. J. Neurosci. (1998)
- Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Pirvola, U., Ylikoski, J., Palgi, J., Lehtonen, E., Arumäe, U., Saarma, M. Proc. Natl. Acad. Sci. U.S.A. (1992)
- The survival-promoting effect of glial cell line-derived neurotrophic factor on axotomized corticospinal neurons in vivo is mediated by an endogenous brain-derived neurotrophic factor mechanism. Giehl, K.M., Schütte, A., Mestres, P., Yan, Q. J. Neurosci. (1998)
- Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Smith, M.A., Makino, S., Kvetnansky, R., Post, R.M. J. Neurosci. (1995)