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Gene Review

Ralgds  -  ral guanine nucleotide dissociation...

Rattus norvegicus

Synonyms: Ral guanine nucleotide dissociation stimulator, Ral guanine nucleotide exchange factor, RalGDS, RalGEF
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High impact information on Ralgds

  • Among the effectors of Ras are the Raf kinase and RalGDS, a guanine nucleotide dissociation stimulator specific for Ral [1].
  • Surprisingly, our analyses of Ras effector domain mutants or constitutively activated effectors indicated that activation of Raf-1, phosphatidylinositol 3-kinase (PI3K), or RalGDS alone is not sufficient to promote Ras inhibition of anoikis [2].
  • Thus, the interaction of RalGDS with Ras and the subsequent activation of Ral are thought to constitute a distinct Ras-dependent signaling pathway [3].
  • Ras effector region mutants V12C40 (tyrosine 40 to cysteine; activates the p110 alpha-subunit of phosphatidylinositol 3-kinase) and V12G37 (glutamic acid 37 to glycine; activates Ral guanine nucleotide dissociation stimulator) had no significant effect on VDCC current [4].

Anatomical context of Ralgds

  • Ral-specific guanine-nucleotide exchange factors such as RalGDS, Rlf and RGL interact with activated Ras and cooperate with Ras in the transformation of murine fibroblasts [2-5] [3].

Regulatory relationships of Ralgds

  • Ral-specific guanine nucleotide exchange factor such as RalGDS interacts with activated Ras and cooperates with Ras indicating that Ral can be activated through Ras signaling pathway [5].

Other interactions of Ralgds

  • Cells expressing RasS35, a mutant which binds Raf, or RasG37, a mutant which binds RalGDS, exhibited TSH-independent proliferation [6].


  1. Structural basis for the interaction of Ras with RalGDS. Huang, L., Hofer, F., Martin, G.S., Kim, S.H. Nat. Struct. Biol. (1998) [Pubmed]
  2. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. McFall, A., Ulkü, A., Lambert, Q.T., Kusa, A., Rogers-Graham, K., Der, C.J. Mol. Cell. Biol. (2001) [Pubmed]
  3. Ras-independent activation of Ral by a Ca(2+)-dependent pathway. Hofer, F., Berdeaux, R., Martin, G.S. Curr. Biol. (1998) [Pubmed]
  4. Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. Fitzgerald, E.M. J. Physiol. (Lond.) (2000) [Pubmed]
  5. Regulation of GTP-binding state in RalA through Ca2+ and calmodulin. Park, J.B. Exp. Mol. Med. (2001) [Pubmed]
  6. Differential effects of protein kinase A on Ras effector pathways. Miller, M.J., Rioux, L., Prendergast, G.V., Cannon, S., White, M.A., Meinkoth, J.L. Mol. Cell. Biol. (1998) [Pubmed]
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