Gene Review:
Raf1 - v-raf-leukemia viral oncogene 1
Rattus norvegicus
Synonyms:
Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase, Raf, Raf-1, cRaf
- Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Galve-Roperh, I., Sánchez, C., Cortés, M.L., del Pulgar, T.G., Izquierdo, M., Guzmán, M. Nat. Med. (2000)
- Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent. Pai, R., Jones, M.K., Tomikawa, M., Tarnawski, A.S. Am. J. Pathol. (1999)
- Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Williams, N.G., Paradis, H., Agarwal, S., Charest, D.L., Pelech, S.L., Roberts, T.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. Della Rocca, G.J., van Biesen, T., Daaka, Y., Luttrell, D.K., Luttrell, L.M., Lefkowitz, R.J. J. Biol. Chem. (1997)
- Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas. McFarlin, D.R., Lindstrom, M.J., Gould, M.N. Carcinogenesis (2003)
- The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus. Kang, U.G., Jeon, S.H., Lee, J.E., Joo, Y.H., Yi, J.S., Park, J.B., Juhnn, Y.S., Kim, Y.S. Neuropharmacology (2000)
- Expression of the Raf-1 protein in rat brain during development and its hormonal regulation in hypothalamus. Whorf, R.C., Tobet, S.A. J. Neurobiol. (1992)
- Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., Evan, G. Nature (1997)
- Phosphatidylinositol-3-OH kinase as a direct target of Ras. Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M.D., Downward, J. Nature (1994)
- Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Lange-Carter, C.A., Johnson, G.L. Science (1994)
- Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Moodie, S.A., Willumsen, B.M., Weber, M.J., Wolfman, A. Science (1993)
- Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Eves, E.M., Shapiro, P., Naik, K., Klein, U.R., Trakul, N., Rosner, M.R. Mol. Cell (2006)
- Oncogenic src, raf, and ras stimulate a hypertrophic pattern of gene expression and increase cell size in neonatal rat ventricular myocytes. Fuller, S.J., Gillespie-Brown, J., Sugden, P.H. J. Biol. Chem. (1998)
- A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. Pracyk, J.B., Tanaka, K., Hegland, D.D., Kim, K.S., Sethi, R., Rovira, I.I., Blazina, D.R., Lee, L., Bruder, J.T., Kovesdi, I., Goldshmidt-Clermont, P.J., Irani, K., Finkel, T. J. Clin. Invest. (1998)
- Angiotensin II induces diverse signal transduction pathways via both Gq and Gi proteins in liver epithelial cells. Tsygankova, O.M., Peng, M., Maloney, J.A., Hopkins, N., Williamson, J.R. J. Cell. Biochem. (1998)
- Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules. Hirasawa, N., Santini, F., Beaven, M.A. J. Immunol. (1995)
- Rapid mitogen-activated protein kinase activation by transforming growth factor alpha in wounded rat intestinal epithelial cells. Göke, M., Kanai, M., Lynch-Devaney, K., Podolsky, D.K. Gastroenterology (1998)
- H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Roy, S., Wyse, B., Hancock, J.F. Mol. Cell. Biol. (2002)
- Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Chung, K.C., Gomes, I., Wang, D., Lau, L.F., Rosner, M.R. Mol. Cell. Biol. (1998)
- Reactive oxygen species modulate angiotensin II-induced beta-myosin heavy chain gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in neonatal rat cardiomyocytes. Shih, N.L., Cheng, T.H., Loh, S.H., Cheng, P.Y., Wang, D.L., Chen, Y.S., Liu, S.H., Liew, C.C., Chen, J.J. Biochem. Biophys. Res. Commun. (2001)
- Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists. Montessuit, C., Thorburn, A. J. Biol. Chem. (1999)
- Differential effects of protein kinase A on Ras effector pathways. Miller, M.J., Rioux, L., Prendergast, G.V., Cannon, S., White, M.A., Meinkoth, J.L. Mol. Cell. Biol. (1998)
- Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells. Rider, L.G., Hirasawa, N., Santini, F., Beaven, M.A. J. Immunol. (1996)
- Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways. Grana, T.M., Rusyn, E.V., Zhou, H., Sartor, C.I., Cox, A.D. Cancer Res. (2002)
- Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Thorburn, J., Carlson, M., Mansour, S.J., Chien, K.R., Ahn, N.G., Thorburn, A. Mol. Biol. Cell (1995)
- Peroxynitrite targets the epidermal growth factor receptor, Raf-1, and MEK independently to activate MAPK. Zhang, P., Wang, Y.Z., Kagan, E., Bonner, J.C. J. Biol. Chem. (2000)
- Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. Gouni-Berthold, I., Seul, C., Ko, Y., Hescheler, J., Sachinidis, A. Hypertension (2001)
- Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases. Palmer, H.J., Tuzon, C.T., Paulson, K.E. J. Biol. Chem. (1999)
- The liver response to in vivo heat shock involves the activation of MAP kinases and RAF and the tyrosine phosphorylation of Shc proteins. Bendinelli, P., Piccoletti, R., Maroni, P., Bernelli-Zazzera, A. Biochem. Biophys. Res. Commun. (1995)
- Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. Winitz, S., Russell, M., Qian, N.X., Gardner, A., Dwyer, L., Johnson, G.L. J. Biol. Chem. (1993)
- Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner. Navarro, P., Valverde, A.M., Benito, M., Lorenzo, M. J. Biol. Chem. (1999)
- Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity. Chan, E.Y., Stang, S.L., Bottorff, D.A., Stone, J.C. Mol. Carcinog. (2002)
- Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation. Pruitt, K., Pruitt, W.M., Bilter, G.K., Westwick, J.K., Der, C.J. J. Biol. Chem. (2002)
- Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation. Lee, J., Hong, F., Kwon, S., Kim, S.S., Kim, D.O., Kang, H.S., Lee, S.J., Ha, J., Kim, S.S. Biochem. Biophys. Res. Commun. (2002)
- cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Yu, S.M., Hung, L.M., Lin, C.C. Circulation (1997)
- Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter. Liu, A., Prenger, M.S., Norton, D.D., Mei, L., Kusiak, J.W., Bai, G. J. Biol. Chem. (2001)
- A PI3K Pathway Mediates Hair Cell Survival and Opposes Gentamicin Toxicity in Neonatal Rat Organ of Corti. Chung, W.H., Pak, K., Lin, B., Webster, N., Ryan, A.F. J. Assoc. Res. Otolaryngol. (2006)
- Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Nakahata, N., Tsuchiya, C., Nakatani, K., Ohizumi, Y., Ohkubo, S. Eur. J. Pharmacol. (2003)
- Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. Dabrowski, A., Groblewski, G.E., Schäfer, C., Guan, K.L., Williams, J.A. Am. J. Physiol. (1997)
- Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf. Liao, D.F., Duff, J.L., Daum, G., Pelech, S.L., Berk, B.C. Circ. Res. (1996)
- Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. Marrero, M.B., Schieffer, B., Li, B., Sun, J., Harp, J.B., Ling, B.N. J. Biol. Chem. (1997)