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Gene Review:

Agtrap - angiotensin II receptor-associated protein

Rattus norvegicus

Synonyms: AT1 receptor-associated protein, Atrap, Type-1 angiotensin II receptor-associated protein

Cui, T. et al., Tanaka, Y. et al.

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High impact information on Agtrap

We previously cloned a novel molecule interacting with the AT1R, which we named ATRAP (for Ang II type 1 receptor-associated protein) [1].
Transfection of ATRAP potentiated AT1 receptor internalization upon Ang II stimulation in these VSMCs [2].
ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth [2].
Moreover, we observed that AT1 receptor-induced DNA synthesis was markedly inhibited in ATRAP transfected VSMCs associated with the inhibition of the phosphorylation of signal transducers and activators of transcription (STAT) 3 and Akt [2].
Our results suggest that ATRAP functions as a negative regulator in AT1 receptor-mediated cell proliferation in VSMCs [2].

References

The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. Tanaka, Y., Tamura, K., Koide, Y., Sakai, M., Tsurumi, Y., Noda, Y., Umemura, M., Ishigami, T., Uchino, K., Kimura, K., Horiuchi, M., Umemura, S. FEBS Lett. (2005) [Pubmed]
ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth. Cui, T., Nakagami, H., Iwai, M., Takeda, Y., Shiuchi, T., Tamura, K., Daviet, L., Horiuchi, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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agtrap	Danio rerio
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agtrap	Xenopus (Silurana) tropicalis

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