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Gene Review:

AGTRAP - angiotensin II receptor-associated protein

Homo sapiens

Synonyms: AT1 receptor-associated protein, ATRAP, Type-1 angiotensin II receptor-associated protein

Guo, S. et al., Oshita, A. et al., Guo, D.F. et al.

Guo, Chenier, Tardif, Orlov, Inagami,

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High impact information on AGTRAP

Functionally, transcriptional reporter assays and RNA interference ATRAP experiments demonstrated that ATRAP knockdown increased nuclear factor of activated T cells (NFAT) activity [1].
A novel AT1 receptor intracellular partner called AT1 receptor-associated protein (ATRAP) was identified, but its exact function has not been elucidated [1].
Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane [2].
In ATRAP transgenic (ATRAP-Tg) mice, ATRAP mRNA was increased 3- to 4-fold in the heart, aorta, and femoral artery [3].

References

Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. Guo, S., Lopez-Ilasaca, M., Dzau, V.J. J. Biol. Chem. (2005) [Pubmed]
Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Guo, D.F., Chenier, I., Tardif, V., Orlov, S.N., Inagami, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Attenuation of Inflammatory Vascular Remodeling by Angiotensin II Type 1 Receptor-Associated Protein. Oshita, A., Iwai, M., Chen, R., Ide, A., Okumura, M., Fukunaga, S., Yoshii, T., Mogi, M., Higaki, J., Horiuchi, M. Hypertension (2006) [Pubmed]

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