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Gene Review:

SAC3D1 - SAC3 domain containing 1

Homo sapiens

Synonyms: HSU79266, SAC3 domain-containing protein 1, SAC3 homology domain-containing protein 1, SHD1

Khuda, S.E. et al., Fukuda, M.

Fukuda,

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High impact information on SAC3D1

Here, we studied the function of a mammalian homologue SHD1 in cell cycle progression [1].
SHD1 is localized on centrosomes at interphase and at spindle poles and mitotic spindles, similar to alpha-tubulin, at M phase [1].
These results demonstrated that shd1 is involved in cell cycle progression, in particular centrosome duplication and a spindle assembly checkpoint function [1].
The SHD consists of two conserved alpha-helical regions (SHD1 and SHD2) that are often separated by two zinc finger motifs [2].

Biological context of SAC3D1

RNA interference suppression of endogenous shd1 caused defects in centrosome duplication and spindle formation displaying cells with a single apparent centrosome and down-regulated Mad2 expression, generating increased micronuclei [1].

Analytical, diagnostic and therapeutic context of SAC3D1

In this study, systematic deletion analysis and Ala-based site-directed mutagenesis showed that SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP-bound form of Rab27A [2].

References

The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. Khuda, S.E., Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K., Sakaguchi, N. J. Biol. Chem. (2004) [Pubmed]
Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. Fukuda, M. J. Biol. Chem. (2002) [Pubmed]

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SAC3D1	Bos taurus
SAC3D1	Canis lupus familiaris
si:zfos-452g4.1	Danio rerio
LOC717043	Macaca mulatta
Sac3d1	Mus musculus
SAC3D1	Pan troglodytes
LOC100489268	Xenopus (Silurana) tropicalis

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