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Gene Review

SAC3D1  -  SAC3 domain containing 1

Homo sapiens

Synonyms: HSU79266, SAC3 domain-containing protein 1, SAC3 homology domain-containing protein 1, SHD1
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High impact information on SAC3D1


Biological context of SAC3D1

  • RNA interference suppression of endogenous shd1 caused defects in centrosome duplication and spindle formation displaying cells with a single apparent centrosome and down-regulated Mad2 expression, generating increased micronuclei [1].

Analytical, diagnostic and therapeutic context of SAC3D1

  • In this study, systematic deletion analysis and Ala-based site-directed mutagenesis showed that SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP-bound form of Rab27A [2].


  1. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. Khuda, S.E., Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K., Sakaguchi, N. J. Biol. Chem. (2004) [Pubmed]
  2. Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
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