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Gene Review

SAC3D1  -  SAC3 domain containing 1

Homo sapiens

Synonyms: HSU79266, SAC3 domain-containing protein 1, SAC3 homology domain-containing protein 1, SHD1
 
 
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High impact information on SAC3D1

 

Biological context of SAC3D1

  • RNA interference suppression of endogenous shd1 caused defects in centrosome duplication and spindle formation displaying cells with a single apparent centrosome and down-regulated Mad2 expression, generating increased micronuclei [1].
 

Analytical, diagnostic and therapeutic context of SAC3D1

  • In this study, systematic deletion analysis and Ala-based site-directed mutagenesis showed that SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP-bound form of Rab27A [2].

References

  1. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. Khuda, S.E., Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K., Sakaguchi, N. J. Biol. Chem. (2004) [Pubmed]
  2. Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
 
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