The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tuba1a  -  tubulin, alpha 1A

Mus musculus

Synonyms: Alpha-tubulin 1, Alpha-tubulin isotype M-alpha-1, Talpha1 alpha-tubulin, Tuba-1, Tuba1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tuba1a


High impact information on Tuba1a


Chemical compound and disease context of Tuba1a


Biological context of Tuba1a

  • Five mouse alpha-tubulin isotypes are described, each distinguished by the presence of unique amino acid substitutions within the coding region [10].
  • The unexpected prevalence of c-myc and alpha-tubulin in the S-phase library is supported by Northern analysis of RNA from phase-synchronous cells [11].
  • In contrast, some populations of astrocytes incorporated nitrotyrosine into alpha-tubulin, but free nitrotyrosine had no effect on the viability and phenotype of astrocytes in culture, as evaluated by glial fibrillary acidic protein immunoreactivity, cell growth and morphology [12].
  • Double-labeling studies showed that Talpha1:nlacZ expression was detectable in the same cells and at approximately the same time as was betaIII-tubulin, indicating that detectable transcription of the Talpha1 alpha-tubulin promoter commences at the time of terminal mitosis, at least in culture [13].
  • Mock transfections had no effect on HSMC contractily, and transfections with small interfering RNAs (siRNAs) specific for HDAC6, a cytosolic HDAC that functions as an alpha-tubulin deacetylase, resulted in a weak contraction inhibition [14].

Anatomical context of Tuba1a

  • Post-transcriptional regulation of the abundance of mRNAs encoding alpha-tubulin and a 94,000-dalton protein in teratocarcinoma-derived stem cells versus differentiated cells [1].
  • In elongating spermatids and residual bodies, the synthesis of alpha tubulin is drastically reduced [15].
  • Recently, we have shown that Hsp105alpha binds to alpha-tubulin and prevents the heat-induced disaggregation of microtubules [16].
  • Our results suggest that a functional relationship may exist between the structure and organization of the Golgi complex and the detyrosination of alpha-tubulin in microtubules [17].
  • The relationship between alpha tubulin detyrosination and microtubule (MT) stability was examined directly in cultured fibroblasts by experimentally converting the predominantly tyrosinated MT array to a detyrosinated (Glu) array and then assaying MT stability [18].

Associations of Tuba1a with chemical compounds

  • Whereas the 1.8-kb mRNA encodes a distinct alpha-tubulin isotype, the 2.4-kb mRNA is defective in that the methionine residue required for translational initiation is missing [10].
  • Clones LG-80, LG-2, and LG-69 are highly homologous to beta-actin, lactate dehydrogenase, and alpha-tubulin [19].
  • In the studies reported here, it was found that inhibitors of polyamine biosynthesis, methylglyoxal-bis[quanylhydrazone] (MGBG) and difluoromethylornithine (DFMO), prevent mitogen-induced accumulation of mRNAs encoding major cytoskeletal components, beta-actin and alpha-tubulin, in mouse splenocytes [20].
  • Tubulin-tyrosine ligase (TTL), the enzyme responsible for the reversible addition of a tyrosine residue at the carboxyl end of alpha-tubulin, has been purified from porcine brain using a purification scheme based on standard biochemical procedures [21].
  • Nocodazole markedly inhibited incorporation of [3H]glutamate into alpha- and beta-tubulin, whereas taxol had no effect for alpha-tubulin and a stimulating effect for beta-tubulin [22].

Regulatory relationships of Tuba1a

  • E2F6-deficient mice ubiquitously express the alpha-tubulin 3 and 7 genes, which are expressed strictly testis-specifically in control mice [23].

Other interactions of Tuba1a


Analytical, diagnostic and therapeutic context of Tuba1a


  1. Post-transcriptional regulation of the abundance of mRNAs encoding alpha-tubulin and a 94,000-dalton protein in teratocarcinoma-derived stem cells versus differentiated cells. Howe, C.C., Lugg, D.K., Overton, G.C. Mol. Cell. Biol. (1984) [Pubmed]
  2. Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. Suwelack, D., Hurtado-Lorenzo, A., Millan, E., Gonzalez-Nicolini, V., Wawrowsky, K., Lowenstein, P.R., Castro, M.G. Gene Ther. (2004) [Pubmed]
  3. Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines. Eddé, B., de Nechaud, B., Denoulet, P., Gros, F. Dev. Biol. (1987) [Pubmed]
  4. Both positive and negative factors regulate gene expression following chronic facial nerve resection. McPhail, L.T., Oschipok, L.W., Liu, J., Tetzlaff, W. Exp. Neurol. (2005) [Pubmed]
  5. Neonatal hypothyroidism - a biochemical disorder of alpha-tubulin metabolism. Lakshmanan, J., Mansfield, H., Weichsel, M.E., Hoath, S., Scott, S., Shapshak, P., Fisher, D.A. Biochem. Biophys. Res. Commun. (1981) [Pubmed]
  6. Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Spiegelman, B.M., Farmer, S.R. Cell (1982) [Pubmed]
  7. HDAC6 is a microtubule-associated deacetylase. Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.F., Yao, T.P. Nature (2002) [Pubmed]
  8. Haploid expression of a mouse testis alpha-tubulin gene. Distel, R.J., Kleene, K.C., Hecht, N.B. Science (1984) [Pubmed]
  9. Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line. Chisu, V., Manca, P., Lepore, G., Gadau, S., Zedda, M., Farina, V. Archives italiennes de biologie. (2006) [Pubmed]
  10. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Villasante, A., Wang, D., Dobner, P., Dolph, P., Lewis, S.A., Cowan, N.J. Mol. Cell. Biol. (1986) [Pubmed]
  11. Cell cycle phase-specific cDNA libraries reflecting phase-specific gene expression of Ehrlich ascites cells growing in vivo. Lu, X., Kopun, M., Werner, D. Exp. Cell Res. (1988) [Pubmed]
  12. Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine. Peluffo, H., Shacka, J.J., Ricart, K., Bisig, C.G., Martìnez-Palma, L., Pritsch, O., Kamaid, A., Eiserich, J.P., Crow, J.P., Barbeito, L., Estèvez, A.G. J. Neurochem. (2004) [Pubmed]
  13. Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system. Gloster, A., El-Bizri, H., Bamji, S.X., Rogers, D., Miller, F.D. J. Comp. Neurol. (1999) [Pubmed]
  14. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. Waltregny, D., Glénisson, W., Tran, S.L., North, B.J., Verdin, E., Colige, A., Castronovo, V. FASEB J. (2005) [Pubmed]
  15. The differential expression of the actins and tubulins during spermatogenesis in the mouse. Hecht, N.B., Kleene, K.C., Distel, R.J., Silver, L.M. Exp. Cell Res. (1984) [Pubmed]
  16. Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. Saito, Y., Doi, K., Yamagishi, N., Ishihara, K., Hatayama, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Spatial and temporal colocalization of the Golgi apparatus and microtubules rich in detyrosinated tubulin. Skoufias, D.A., Burgess, T.L., Wilson, L. J. Cell Biol. (1990) [Pubmed]
  18. Detyrosination of alpha tubulin does not stabilize microtubules in vivo. Webster, D.R., Wehland, J., Weber, K., Borisy, G.G. J. Cell Biol. (1990) [Pubmed]
  19. Molecular cloning of transcripts that accumulate during the late G1 phase in cultured mouse cells. Nikaido, T., Bradley, D.W., Pardee, A.B. Exp. Cell Res. (1991) [Pubmed]
  20. Inhibitors of polyamine biosynthesis affect the expression of genes encoding cytoskeletal proteins. Kamińska, B., Kaczmarek, L., Grzelakowska-Sztabert, B. FEBS Lett. (1992) [Pubmed]
  21. Purification of brain tubulin-tyrosine ligase by biochemical and immunological methods. Schröder, H.C., Wehland, J., Weber, K. J. Cell Biol. (1985) [Pubmed]
  22. Reversible polyglutamylation of alpha- and beta-tubulin and microtubule dynamics in mouse brain neurons. Audebert, S., Desbruyères, E., Gruszczynski, C., Koulakoff, A., Gros, F., Denoulet, P., Eddé, B. Mol. Biol. Cell (1993) [Pubmed]
  23. A role for E2F6 in the restriction of male-germ-cell-specific gene expression. Pohlers, M., Truss, M., Frede, U., Scholz, A., Strehle, M., Kuban, R.J., Hoffmann, B., Morkel, M., Birchmeier, C., Hagemeier, C. Curr. Biol. (2005) [Pubmed]
  24. Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies. Iwabata, H., Yoshida, M., Komatsu, Y. Proteomics (2005) [Pubmed]
  25. Differential expression and localisation of connexin-37 and connexin-43 in follicles of different stages in the 4-week-old mouse ovary. Teilmann, S.C. Mol. Cell. Endocrinol. (2005) [Pubmed]
  26. Age-related differential mRNA expression of T cell cytokines in NZB/NZW F1 mice. Yoshii, H., Yamamoto, K., Okudaira, H., Dohi, M., Suko, M., Fukata, Y., Yago, H., Suehiro, S., Ito, K. Lupus (1995) [Pubmed]
  27. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. Slack, R.S., El-Bizri, H., Wong, J., Belliveau, D.J., Miller, F.D. J. Cell Biol. (1998) [Pubmed]
  28. A vital role of tubulin-tyrosine-ligase for neuronal organization. Erck, C., Peris, L., Andrieux, A., Meissirel, C., Gruber, A.D., Vernet, M., Schweitzer, A., Saoudi, Y., Pointu, H., Bosc, C., Salin, P.A., Job, D., Wehland, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  29. Stage-dependent Dishevelled-1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes. Ma, P., Wang, H., Guo, R., Ma, Q., Yu, Z., Jiang, Y., Ge, Y., Ma, J., Xue, S., Han, D. Mol. Reprod. Dev. (2006) [Pubmed]
  30. Casein, actin, and tubulin expression during early involution in bovine and murine mammary tissue. Wiens, D.J., Brooks, C.L., Hodgson, C.P. J. Dairy Sci. (1992) [Pubmed]
  31. Posttranslational processing of alpha-tubulin during axoplasmic transport in CNS axons. Brown, B.A., Nixon, R.A., Marotta, C.A. J. Cell Biol. (1982) [Pubmed]
  32. Localization of a highly divergent mammalian testicular alpha tubulin that is not detectable in brain. Hecht, N.B., Distel, R.J., Yelick, P.C., Tanhauser, S.M., Driscoll, C.E., Goldberg, E., Tung, K.S. Mol. Cell. Biol. (1988) [Pubmed]
  33. Association of the Ste20-like kinase (SLK) with the microtubule. Role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading. Wagner, S., Flood, T.A., O'Reilly, P., Hume, K., Sabourin, L.A. J. Biol. Chem. (2002) [Pubmed]
WikiGenes - Universities