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Gene Review

GLTSCR1  -  glioma tumor suppressor candidate region...

Homo sapiens

Synonyms: Glioma tumor suppressor candidate region gene 1 protein
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Disease relevance of GLTSCR1

  • Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01) [1].
  • It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (P = 0.02, log-rank test) [1].

High impact information on GLTSCR1


  1. Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. Yang, P., Kollmeyer, T.M., Buckner, K., Bamlet, W., Ballman, K.V., Jenkins, R.B. Cancer (2005) [Pubmed]
  2. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Pohl, U., Smith, J.S., Tachibana, I., Ueki, K., Lee, H.K., Ramaswamy, S., Wu, Q., Mohrenweiser, H.W., Jenkins, R.B., Louis, D.N. Genomics (2000) [Pubmed]
  3. ERCC1 and ERCC2 polymorphisms and adult glioma. Wrensch, M., Kelsey, K.T., Liu, M., Miike, R., Moghadassi, M., Sison, J.D., Aldape, K., McMillan, A., Wiemels, J., Wiencke, J.K. Neuro-oncology (2005) [Pubmed]
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