Disease relevance of GLTSCR2

• However, the results might warrant clarification in additional series in conjunction with the nearby putative glioma suppressor genes (GLTSCR1 and GLTSCR2) [1].
• A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection [2].
• Properties of Moloney sarcoma virus-specific p60 and its detection in transformed cells [3].

High impact information on GLTSCR2

• The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication [4].
• Recombinant p60 was purified in 8 M urea and dialyzed against buffer [5].
• They contain repeated valine- and proline-rich motifs of 12 residues with the consensus VPVP--V-V-V-. In p60 the central core domain consists of 24 tandemly repeated VPV motifs [5].
• We have copurified a membrane-associated tyrosine kinase (p93) and an activity associated with both the cytosol and membrane fractions (p60) [6].
• These results suggest that, although p93 and p60 may possess some epitopic similarities, they have distinguishing phosphorylation sites [6].

Biological context of GLTSCR2

• The p60 shows as remarkable characteristic a genetic polymorphism with two different alleles [7].

Anatomical context of GLTSCR2

• These results support a model in which katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein [8].
• Antipeptide antibodies against one of the autophosphorylation site sequences recognized a single p60 protein in the purified placenta preparation or Jurkat cell extracts [9].
• The human p60 (Mr 60,000) is an abundant protein in the two-dimensional electrophoresis pattern of the cellular proteins of human mitogen-stimulated lymphocytes [7].

Regulatory relationships of GLTSCR2

• In addition to phosphorylating PTEN, GLTSCR2 induces caspase-independent PTEN-modulated apoptotic cell death when overexpressed [10].

Analytical, diagnostic and therapeutic context of GLTSCR2

• A monoclonal antibody was prepared against avian p60; Western immunoblot analysis showed that p60 was present in each of eight chick tissues examined and in each of the human, rat, rabbit, and Xenopus tissues tested [11].
• We report the crystal structure of an ASF1a-HIRA heterodimer and a biochemical dissection of ASF1a's mutually exclusive interactions with HIRA and the p60 subunit of CAF-1 [12].

References