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Gene Review

EHD2  -  EH-domain containing 2

Homo sapiens

Synonyms: EH domain-containing protein 2, PAST homolog 2, PAST2
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Disease relevance of EHD2

  • The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2) [1].

High impact information on EHD2


Anatomical context of EHD2

  • EHD2 in rat adipocytes was 85% membrane-associated, including approximately 10% in immunopurified GLUT4 vesicles [4].

Associations of EHD2 with chemical compounds


Other interactions of EHD2

  • High expression of EHD2 or EHBP1 in intact cells mediates extensive actin reorganization [3].
  • This association of EHD2 with GLUT4 vesicles occurred in PM and three distinct endosomal fractions and was not significantly affected by cellular insulin treatment [4].

Analytical, diagnostic and therapeutic context of EHD2

  • On the basis of MALDI-TOF MS, RT-PCR, gene cloning, protein sequencing, and immunoreactivity data, we identified this protein as EHD2, a member of the EH domain-containing proteins that have been implicated in vesicle trafficking [4].
  • In co-immunoprecipitation experiments, however, EHD2 physically interacted with GLUT4 in each of these fractions, and cellular insulin treatment selectively enhanced this interaction in an endosomal fraction thought to contain GLUT4 exocytic vesicles [4].


  1. Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. Yang, P., Kollmeyer, T.M., Buckner, K., Bamlet, W., Ballman, K.V., Jenkins, R.B. Cancer (2005) [Pubmed]
  2. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. Guilherme, A., Soriano, N.A., Furcinitti, P.S., Czech, M.P. J. Biol. Chem. (2004) [Pubmed]
  3. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. Guilherme, A., Soriano, N.A., Bose, S., Holik, J., Bose, A., Pomerleau, D.P., Furcinitti, P., Leszyk, J., Corvera, S., Czech, M.P. J. Biol. Chem. (2004) [Pubmed]
  4. EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment. Park, S.Y., Ha, B.G., Choi, G.H., Ryu, J., Kim, B., Jung, C.Y., Lee, W. Biochemistry (2004) [Pubmed]
  5. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Pohl, U., Smith, J.S., Tachibana, I., Ueki, K., Lee, H.K., Ramaswamy, S., Wu, Q., Mohrenweiser, H.W., Jenkins, R.B., Louis, D.N. Genomics (2000) [Pubmed]
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