Gene Review:
Sp7 - Sp7 transcription factor
Rattus norvegicus
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Disease relevance of Sp7
- The Sp7 mRNA was expressed in human foetal osteoblasts and craniofacial osteoblasts, chondrocytes and the osteosarcoma cell lines HOS and MG63, but was not detected in adult femoral osteoblasts [1].
High impact information on Sp7
- CONCLUSIONS: Sp7 expression in humans is largely confined to osteoblasts and chondrocytes, both of which differentiate from the mesenchymal lineage [1].
- The human Sp7 protein is a member of the Sp family having 78% identity with Sp1 in the three, Cys2-His2 type, DNA-binding zinc-fingers, but there is little homology elsewhere [1].
References
- Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. Milona, M.A., Gough, J.E., Edgar, A.J. BMC Genomics (2003) [Pubmed]
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