The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

zic1  -  zic family member 1 (odd-paired homolog,...

Danio rerio

Synonyms: SO:0000704, opl, wu:fj51c06, zgc:136736
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on zic1

  • Zebrafish early gastrula ectodermal explants are specified to express the neural markers opl (zic1) and otx2, and this expression is prevented by BMP4 [1].
  • Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse [2].
  • Here zic1 marks cells that are distinct from the main adaxial somite portion, the future myomere. zic1 expression in the somites is expanded in swirl but reduced in shh injected embryos, suggesting these factors have opposing activity in dorsoventral patterning of the somites [3].
  • Later, a growing mass of zic1 expressing cells occurs in a dorsal mesenchyme that eventually invades the dorsal fin fold, suggesting a somitic contribution to the dorsal fin mesenchyme [3].

Anatomical context of zic1

  • During somitogenesis zic1 is expressed in the dorsal most part of the developing somites [3].


  1. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Sagerström, C.G., Gammill, L.S., Veale, R., Sive, H. Dev. Dyn. (2005) [Pubmed]
  2. Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. Ohtsuka, M., Kikuchi, N., Ozato, K., Inoko, H., Kimura, M. Genomics (2004) [Pubmed]
  3. Zebrafish zic1 expression in brain and somites is affected by BMP and hedgehog signalling. Rohr, K.B., Schulte-Merker, S., Tautz, D. Mech. Dev. (1999) [Pubmed]
WikiGenes - Universities