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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hoxa13b  -  homeobox A13b

Danio rerio

Synonyms: HOXA13, Homeobox protein Hox-A13b, Hox-A13, Hoxa-13, SO:0000704, ...
 
 
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High impact information on hoxa13b

  • We conclude that the early expression pattern in tetrapods is similar to that seen in late fin development and that the local exclusion by Hoxa-13 of Hoxa-11 from the distal limb bud is a derived feature of limb developmental regulation [1].
  • There is, however, a short period of limb bud development where Hoxa-11 and Hoxa-13 overlap similarly to the late expression seen in zebrafish and paddlefish [1].
  • In tetrapod limb development Hoxa-11 plays a key role in differentiating the lower limb and Hoxa-13 plays a key role in differentiating the autopodium [1].
 

Other interactions of hoxa13b

  • During fin regeneration, hoxa11b and hoxa13b genes are both induced in undifferentiated cells of the distalmost blastema region (DMB) and the proliferating zone (PZ) and later in differentiating bone-forming cells [2].

References

  1. Expression of Hoxa-11 and Hoxa-13 in the pectoral fin of a basal ray-finned fish, Polyodon spathula: implications for the origin of tetrapod limbs. Metscher, B.D., Takahashi, K., Crow, K., Amemiya, C., Nonaka, D.F., Wagner, G.P. Evol. Dev. (2005) [Pubmed]
  2. Posterior hoxa genes expression during zebrafish bony fin ray development and regeneration suggests their involvement in scleroblast differentiation. Géraudie, J., Borday Birraux, V. Dev. Genes Evol. (2003) [Pubmed]
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