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Gene Review

lhx3  -  LIM homeobox 3

Danio rerio

Synonyms: Homeobox protein LIM-3, LIM homeobox protein 3, LIM/homeobox protein Lhx3, SO:0000704, lim3
 
 
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High impact information on lhx3

  • We show that Fgf3 signaling from the ventral diencephalon is required in a non-cell autonomous fashion to induce the expression of lim3, pit1 and other pituitary-specific genes in the underlying adenohypophyseal progenitor cells [1].
  • Further, induction of islet1 and lim3 expression in the eye at 2 days postfertilization (dpf) was suppressed in mbx-MO-injected embryos [2].
  • Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects [3].
  • The early adenohypophysis anlage of normal zebrafish expresses lim3 and six3 but in yot(ty119) mutants the anterior part of the anlage lacks lim3 expression, and instead produces a crystallin-expressing cell population which develops into a large lens structure expressing beta and gamma-crystallins, but is not associated with retina tissues [4].

References

  1. Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis. Herzog, W., Sonntag, C., von der Hardt, S., Roehl, H.H., Varga, Z.M., Hammerschmidt, M. Development (2004) [Pubmed]
  2. The homeobox gene mbx is involved in eye and tectum development. Kawahara, A., Chien, C.B., Dawid, I.B. Dev. Biol. (2002) [Pubmed]
  3. Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Glasgow, E., Karavanov, A.A., Dawid, I.B. Dev. Biol. (1997) [Pubmed]
  4. Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., Karlstrom, R.O. Mech. Dev. (2000) [Pubmed]
 
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