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Gene Review

msxb  -  muscle segment homeobox B

Danio rerio

Synonyms: Homeobox protein MSH-B, SO:0000704, msh-B, msh-b, mshB, ...
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High impact information on msxb

  • Further, msxe and msxb are upregulated in hand2 mutant ventral arches [1].
  • However, msxb-expressing blastemal cells immediately distal to this proliferative region did not induce mps1 and were retained in mutants [2].
  • We show that during early regeneration, proliferating blastemal cells express msxb, a homeodomain transcriptional repressor [3].
  • Bromodeoxyuridine pulse-chase experiments show that distal and proximal blastemal cells are formed from proliferating, msxb-positive blastemal cells, not from preexisting slow-cycling cells [3].
  • Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb [4].

Other interactions of msxb

  • Morpholino oligonucleotides against fgfr1 and msxb were utilized and knock-down of both proteins resulted in reduced fin outgrowth [4].
  • Furthermore, this method provided direct evidence for a functional role for msxb in caudal fin regeneration [4].


  1. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Miller, C.T., Yelon, D., Stainier, D.Y., Kimmel, C.B. Development (2003) [Pubmed]
  2. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Poss, K.D., Nechiporuk, A., Hillam, A.M., Johnson, S.L., Keating, M.T. Development (2002) [Pubmed]
  3. A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. Nechiporuk, A., Keating, M.T. Development (2002) [Pubmed]
  4. Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Thummel, R., Bai, S., Sarras, M.P., Song, P., McDermott, J., Brewer, J., Perry, M., Zhang, X., Hyde, D.R., Godwin, A.R. Dev. Dyn. (2006) [Pubmed]
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