The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

hand2  -  heart and neural crest derivatives...

Danio rerio

Synonyms: Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, Heart-and neural crest derivatives-expressed protein 2, SO:0000704, dHAND, dhand, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on hand2

  • Using the zebrafish hand2 deletion mutant hands off, we have now investigated the physiological role of hand2 in the development of sympathetic ganglia [1].
  • First we show that edn1-expressing cells in the first (mandibular) and second (hyoid) pharyngeal arch primordia are located most ventrally and surrounded by hand2-expressing cells [2].
  • In hand2 mutants, bapx1 expression is present at the joint region, and expanded ventrally [2].
  • In addition, expression of eng2, normally restricted to first arch dorsal mesoderm, expands ventrally in hand2 and edn1 mutants [2].
  • Studies of mutants with morphogenetic defects have indicated at least six genes that are essential for cardiac fusion and heart tube assembly, including casanova, bonnie and clyde, gata5, one-eyed pinhead, hand2, miles apart, and heart and soul [3].
 

Other interactions of hand2

  • Similar to edn1, hand2 is required for ventral pharyngeal cartilage formation [2].

References

  1. The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons. Lucas, M.E., M??ller, F., R??diger, R., Henion, P.D., Rohrer, H. Development (2006) [Pubmed]
  2. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Miller, C.T., Yelon, D., Stainier, D.Y., Kimmel, C.B. Development (2003) [Pubmed]
  3. Cardiac patterning and morphogenesis in zebrafish. Yelon, D. Dev. Dyn. (2001) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities