Gene Review:
Hcrt - hypocretin
Mus musculus
Synonyms:
Hypocretin, Orexin, Ox, Ppox, orexin A, ...
Sakurai,
Kilduff,
Y. Anzawa,
Muraki,
Crowder,
Yanagisawa,
Chemelli,
Akerman,
Yamamoto,
Matsukura,
Morairty,
Nakazato,
T. Sakurai,
Hara,
Yamanaka,
Sakurai,
Yamashita,
Kilduff,
Shibuya,
Sinton,
Zhang,
Adomako-Mensah,
Nomura,
Tsujino,
Ichiki,
Date,
Ueta,
Kreek,
Serino,
E. Tokai,
Yamanaka,
Y. Soeda,
I. Kimura,
Jedstedt,
T. Wada,
T. Sasaoka,
Flemström,
Goto,
Yuferov,
S. Murata,
Mignot,
Zhou,
M. Yanagisawa,
H. Tsuneki,
Ho,
Xie,
Lewinter,
Sjöblom,
Willie,
Xu,
- Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models. Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M., Nishino, S. Peptides (2006)
- To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Willie, J.T., Chemelli, R.M., Sinton, C.M., Yanagisawa, M. Annu. Rev. Neurosci. (2001)
- The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus. Moriguchi, T., Sakurai, T., Takahashi, S., Goto, K., Yamamoto, M. J. Biol. Chem. (2002)
- High level of orexin A observed in the phenylketonuria mouse brain is due to the abnormal expression of prepro-orexin. Surendran, S., Rady, P.L., Szucs, S., Michals-Matalon, K., Tyring, S.K., Matalon, R. Biochem. Biophys. Res. Commun. (2004)
- Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E., Yanagisawa, M. Neuron (2003)
- Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K., Sugiyama, F., Goto, K., Yanagisawa, M., Sakurai, T. Neuron (2003)
- GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. Xie, X., Crowder, T.L., Yamanaka, A., Morairty, S.R., Lewinter, R.D., Sakurai, T., Kilduff, T.S. J. Physiol. (Lond.) (2006)
- Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Terao, A., Apte-Deshpande, A., Morairty, S., Freund, Y.R., Kilduff, T.S. Neurosci. Lett. (2002)
- Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B., Yanagisawa, M. Cell (1999)
- Attenuated defense response and low basal blood pressure in orexin knockout mice. Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y., Kuwaki, T. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003)
- Arousal effect of orexin A depends on activation of the histaminergic system. Huang, Z.L., Qu, W.M., Li, W.D., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. Yamanaka, A., Muraki, Y., Ichiki, K., Tsujino, N., Kilduff, T.S., Goto, K., Sakurai, T. J. Neurophysiol. (2006)
- Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Willie, J.T., Renthal, W., Chemelli, R.M., Miller, M.S., Scammell, T.E., Yanagisawa, M., Sinton, C.M. Neuroscience (2005)
- Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin. Flemström, G., Sjöblom, M., Jedstedt, G., Akerman, K.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- A commentary on the neurobiology of the hypocretin/orexin system. Mignot, E. Neuropsychopharmacology (2001)
- Down regulation of the prepro-orexin gene expression in genetically obese mice. Yamamoto, Y., Ueta, Y., Date, Y., Nakazato, M., Hara, Y., Serino, R., Nomura, M., Shibuya, I., Matsukura, S., Yamashita, H. Brain Res. Mol. Brain Res. (1999)
- Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy. Burlet, S., Tyler, C.J., Leonard, C.S. J. Neurosci. (2002)
- Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects. Stricker-Krongrad, A., Richy, S., Beck, B. Regul. Pept. (2002)
- Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal. Huang, H., Ghosh, P., van den Pol, A.N. J. Neurophysiol. (2006)
- Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. Kohlmeier, K.A., Inoue, T., Leonard, C.S. J. Neurophysiol. (2004)
- Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice. Zhou, Y., Adomako-Mensah, J., Yuferov, V., Ho, A., Zhang, J., Xu, M., Kreek, M.J. Synapse (2007)
- Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. Tsuneki, H., Murata, S., Anzawa, Y., Soeda, Y., Tokai, E., Wada, T., Kimura, I., Yanagisawa, M., Sakurai, T., Sasaoka, T. Diabetologia (2008)
- Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. Xie, X., Wisor, J.P., Hara, J., Crowder, T.L., LeWinter, R., Khroyan, T.V., Yamanaka, A., Diano, S., Horvath, T.L., Sakurai, T., Toll, L., Kilduff, T.S. J. Clin. Invest. (2008)
- Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Hara, J., Yanagisawa, M., Sakurai, T. Neurosci. Lett. (2005)
- Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. Fu, L.Y., Acuna-Goycolea, C., van den Pol, A.N. J. Neurosci. (2004)
- Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A.J., Sakurai, T., Kilduff, T.S., Horvath, T.L., de Lecea, L. J. Neurosci. (2004)
- Ghrelin-induced food intake is mediated via the orexin pathway. Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M.S., Shimbara, T., Guan, J.L., Wang, Q.P., Funahashi, H., Sakurai, T., Shioda, S., Matsukura, S., Kangawa, K., Nakazato, M. Endocrinology (2003)
- Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Asakawa, A., Inui, A., Yuzuriha, H., Ueno, N., Katsuura, G., Fujimiya, M., Fujino, M.A., Niijima, A., Meguid, M.M., Kasuga, M. Gastroenterology (2003)
- Inactivation of the GR in the nervous system affects energy accumulation. Kellendonk, C., Eiden, S., Kretz, O., Schütz, G., Schmidt, I., Tronche, F., Simon, E. Endocrinology (2002)
- Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., Shibata, S. Eur. J. Neurosci. (2004)
- Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. Chen, J., Randeva, H.S. Mol. Endocrinol. (2004)
- Behavioral state instability in orexin knock-out mice. Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T., Scammell, T.E. J. Neurosci. (2004)