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Gene Review

STAT3  -  signal transducer and activator of...

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Disease relevance of STAT3

  • To define the molecular mechanisms involved, the effect of peroxynitrite was determined on the activation of two transcription factors known to regulate VEGF expression during hypoxia and tumor angiogenesis-signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor-1 (HIF-1) [1].
  • CONCLUSIONS: The present study showed that STAT3 is expressed and activated in kidneys of rats with modified immune complex glomerulonephritis [2].
  • IL-6 signaling is activated during human chronic atrophic gastritis with Helicobacter pylori infection, and aberrant Stat3 signaling activation gives rise to mouse gastric tumors [3].

High impact information on STAT3


Chemical compound and disease context of STAT3


Biological context of STAT3


Anatomical context of STAT3


Associations of STAT3 with chemical compounds

  • BK also activates the mitogen-activated p44 and p42 protein kinases, resulting in STAT3 serine phosphorylation [7].
  • Activation results in the tyrosine phosphorylation and subsequent nuclear translocation of STAT3 [7].
  • LPS-responsive regions of the promoter were localized to the region from -1029 to -543 containing one STAT3 site and two NF-kappaB sites, and the region from -4355 to -2462 containing three AP1 sites and six NF-kappaB sites [8].
  • Finally, fosinopril downregulated STAT3 activation and ED-1 influx, which are effects that may attenuate renal damage in this model [2].
  • Conversely, exposure of ECs to a NOS inhibitor reversed the effects of resveratrol upon IL-6-induced STAT3 phosphorylation [6].

Enzymatic interactions of STAT3

  • In contrast, nuclear levels of STAT-1 and phosphorylated STAT-3 were elevated in a time-dependent manner in response to IFNgamma treatment [9].

Other interactions of STAT3


Analytical, diagnostic and therapeutic context of STAT3


  1. Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Platt, D.H., Bartoli, M., El-Remessy, A.B., Al-Shabrawey, M., Lemtalsi, T., Fulton, D., Caldwell, R.B. Free Radic. Biol. Med. (2005) [Pubmed]
  2. Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. Zhang, W., Chen, X., Shi, S., Wei, R., Wang, J., Yamanaka, N., Hong, Q. Nephrol. Dial. Transplant. (2005) [Pubmed]
  3. STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Katoh, M., Katoh, M. Int. J. Mol. Med. (2007) [Pubmed]
  4. Shear flow attenuates serum-induced STAT3 activation in endothelial cells. Ni, C.W., Hsieh, H.J., Chao, Y.J., Wang, D.L. J. Biol. Chem. (2003) [Pubmed]
  5. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Boelhauve, M., Sinowatz, F., Wolf, E., Paula-Lopes, F.F. Biol. Reprod. (2005) [Pubmed]
  6. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Wung, B.S., Hsu, M.C., Wu, C.C., Hsieh, C.W. Life Sci. (2005) [Pubmed]
  7. Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae. Ju, H., Venema, V.J., Liang, H., Harris, M.B., Zou, R., Venema, R.C. Biochem. J. (2000) [Pubmed]
  8. Characterization of the infection-responsive bovine lactoferrin promoter. Zheng, J., Ather, J.L., Sonstegard, T.S., Kerr, D.E. Gene (2005) [Pubmed]
  9. Mediators of interferon gamma-initiated signaling in bovine luteal cells. Suter, J., Hendry, I.R., Ndjountche, L., Obholz, K., Pru, J.K., Davis, J.S., Rueda, B.R. Biol. Reprod. (2001) [Pubmed]
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