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STAT3  -  signal transducer and activator of...

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  • Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts [2].
  • Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth [3].
  • In addition, we identify a second, 100-kDa form of STAT3 that appears in response to CNTF [1].
  • Here we show that CNTF induced the rapid tyrosine phosphorylation and nuclear accumulation of this protein and identify it as an avian form of the transcription factor, STAT3 [1].
  • Unlike previous reports, utilizing mammalian cell lines that detected a slower migrating form of STAT3 resulting from H7-sensitive protein phosphorylation, H7 did not prevent the appearance of the 100-kDa form in ciliary neurons [1].

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  1. Ciliary neurotrophic factor stimulates the phosphorylation of two forms of STAT3 in chick ciliary ganglion neurons. Wishingrad, M.A., Koshlukova, S., Halvorsen, S.W. J. Biol. Chem. (1997) [Pubmed]
  2. Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts. Uttamsingh, S., Zong, C.S., Wang, L.H. J. Biol. Chem. (2003) [Pubmed]
  3. The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation. Nguyen, K.T., Zong, C.S., Uttamsingh, S., Sachdev, P., Bhanot, M., Le, M.T., Chan, J.L., Wang, L.H. J. Biol. Chem. (2002) [Pubmed]
  4. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. Uckun, F., Ozer, Z., Vassilev, A. Br. J. Haematol. (2007) [Pubmed]
  5. Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia. Holst, A., Heller, S., Junghans, D., Geissen, M., Ernsberger, U., Rohrer, H. Dev. Biol. (1997) [Pubmed]
  6. Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. Ebong, S., Chepelinsky, A.B., Robinson, M.L., Zhao, H., Yu, C.R., Egwuagu, C.E. Mol. Vis. (2004) [Pubmed]
  7. In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. Valdembri, D., Serini, G., Vacca, A., Ribatti, D., Bussolino, F. FASEB J. (2002) [Pubmed]
  8. Retinoic acid up-regulates ciliary neurotrophic factor receptors in cultured chick neurons and cardiomyocytes. Wang, X., Halvorsen, S.W. Neurosci. Lett. (1998) [Pubmed]
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