Disease relevance of HHV5wtgp117

• Sequence variability of the alpha-chemokine UL146 from clinical strains of human cytomegalovirus [1].

High impact information on HHV5wtgp117

• We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode alpha -chemokines: UL146 and UL147 [2].
• Thus, although UL146 and UL74 exhibit impressive variation among strains, their sequences are maintained stably within and between infected individuals, suggesting that sequence differences between genotypes may be driven by differing gene function [3].
• CONCLUSIONS: Sequence variability among HCMV clinical strains may affect the ability of UL146 and UL147 to attract human neutrophils and influence viral dissemination [4].
• This research was to study the sequence variability of UL146 and UL147 ORFs in HCMV clinical isolates and examine the possible associations between gene variability and the outcome of HCMV infection [4].
• RESULTS: The region of the HCMV genome from UL146 through UL147A was analyzed in clinical strains for sequence variability, genotypic stability, and transcriptional expression [5].

Biological context of HHV5wtgp117

• Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome [2].

Analytical, diagnostic and therapeutic context of HHV5wtgp117

• However, genetic changes were highly conserved in individuals and in renal transplant recipients multiple genotypes of UL146 were present [1].
• METHODS: UL146 and UL147 genes from strains obtained from suspected congenitally HCMV-infected infants were PCR amplified and sequenced [4].

References