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Gene Review:

UL147 - contains signal peptide; putative secreted...

Human herpesvirus 5

He, R. et al., Arav-Boger, R. et al., Wang, W. et al.

Arav-Boger, Foster, Zong, Pass,

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Disease relevance of HHV5wtgp116

Sequence variability of human cytomegalovirus UL146 and UL147 genes in low-passage clinical isolates [1].

High impact information on HHV5wtgp116

We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode alpha -chemokines: UL146 and UL147 [2].
CONCLUSIONS: Sequence variability among HCMV clinical strains may affect the ability of UL146 and UL147 to attract human neutrophils and influence viral dissemination [1].
By specific deletion of UL147 and the recombinant GFP gene, we have shown that targeted deletion of a gene and selection for a recombinant genome are coupled with the ability to amplify the BAC clone DNA [3].

Biological context of HHV5wtgp116

Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome [2].
This research was to study the sequence variability of UL146 and UL147 ORFs in HCMV clinical isolates and examine the possible associations between gene variability and the outcome of HCMV infection [1].

Analytical, diagnostic and therapeutic context of HHV5wtgp116

METHODS: UL146 and UL147 genes from strains obtained from suspected congenitally HCMV-infected infants were PCR amplified and sequenced [1].

References

Sequence variability of human cytomegalovirus UL146 and UL147 genes in low-passage clinical isolates. He, R., Ruan, Q., Qi, Y., Ma, Y.P., Huang, Y.J., Sun, Z.R., Ji, Y.H. Intervirology (2006) [Pubmed]
Human cytomegalovirus-encoded alpha -chemokines exhibit high sequence variability in congenitally infected newborns. Arav-Boger, R., Foster, C.B., Zong, J.C., Pass, R.F. J. Infect. Dis. (2006) [Pubmed]
Coupling generation of cytomegalovirus deletion mutants and amplification of viral BAC clones. Wang, W., Patterson, C.E., Yang, S., Zhu, H. J. Virol. Methods (2004) [Pubmed]

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