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Gene Review

UL144  -  type 1 membrane protein; similar to TNFR;...

Human herpesvirus 5

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Disease relevance of HHV5wtgp119

  • The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism [1].
  • Specific Abs to UL144 can be detected in the serum of a subset of HCMV seropositive individuals infected with HIV [2].
  • Comparing between UL144 sequences and the corresponding symptoms showed that genotype 2 did not exist in megacolon isolates [3].

High impact information on HHV5wtgp119

  • The UL144 open reading frame found in clinical isolates of human CMV (HCMV) encodes a structural homologue of the herpesvirus entry mediator, a member of the TNFR superfamily [2].
  • UL144 is a type I transmembrane glycoprotein that is expressed early after infection of fibroblasts; however, it is retained intracellularly [2].
  • Application of UL144 molecular typing to determine epidemiology of cytomegalovirus infections in preterm infants [4].
  • The UL144 sequences were distributed among five genotypes (A, B, C, AC, and AB), as previously described [5].
  • In order to confirm or refute this finding, we determined the UL144 polymorphisms of HCMV strains recovered from the amniotic fluids of 38 infected fetuses and compared them to HCMV strains obtained from 30 viremic adult controls [5].

Chemical compound and disease context of HHV5wtgp119

  • To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor-like receptor gene and the UL55 envelope glycoprotein B gene from 42 patients with congenital human cytomegalovirus (HCMV) infection or other diseases were sequenced [6].

Biological context of HHV5wtgp119

  • Forty-eight of the 49 HCMV isolates yielding UL144 amplicons was grouped according to the clades described a few years ago [Lurain et al. (1999) Journal of Virology 73:10040-10050] [7].
  • Four Texas and 11 Iowa isolates displayed > or = 95% sequence homology for a sequence and UL144 regions and possessed identical gB genotypes [7].
  • The hypervariable region of the HCMV genome, that is the a sequence and UL144 region was analyzed using the polymerase chain reaction (PCR) and unrooted phylogenetic trees [8].

Anatomical context of HHV5wtgp119

  • In our series, all five UL144 genotypes could be vertically transmitted from mothers to fetuses, and all could cause symptomatic congenital infection [5].

Analytical, diagnostic and therapeutic context of HHV5wtgp119

  • Sequence analysis of the UL144 ORF in 45 low-passage clinical isolates demonstrated significant strain-specific variability [9].


  1. The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism. Poole, E., King, C.A., Sinclair, J.H., Alcami, A. EMBO J. (2006) [Pubmed]
  2. Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus. Benedict, C.A., Butrovich, K.D., Lurain, N.S., Corbeil, J., Rooney, I., Schneider, P., Tschopp, J., Ware, C.F. J. Immunol. (1999) [Pubmed]
  3. Sequence variability of human cytomegalovirus UL144 open reading frame in low-passage clinical isolates. He, R., Ruan, Q., Xia, C., Liu, L.Q., Lü, S.M., Lu, Y., Qi, Y., Ma, Y.P., Liu, Q., Ji, Y.H. Chin. Med. Sci. J. (2004) [Pubmed]
  4. Application of UL144 molecular typing to determine epidemiology of cytomegalovirus infections in preterm infants. Stranska, R., Schuurman, R., Toet, M., Verboon-Maciolek, M., de Vries, L.S., van Loon, A.M. J. Clin. Microbiol. (2006) [Pubmed]
  5. Human cytomegalovirus UL144 gene polymorphisms in congenital infections. Picone, O., Costa, J.M., Chaix, M.L., Ville, Y., Rouzioux, C., Leruez-Ville, M. J. Clin. Microbiol. (2005) [Pubmed]
  6. Analysis of human cytomegalovirus UL144 variability in low-passage clinical isolates in Japan. Murayama, T., Takegoshi, M., Tanuma, J., Eizuru, Y. Intervirology (2005) [Pubmed]
  7. Human cytomegalovirus a sequence and UL144 variability in strains from infected children. Bale, J.F., Petheram, S.J., Robertson, M., Murph, J.R., Demmler, G. J. Med. Virol. (2001) [Pubmed]
  8. Human cytomegalovirus genetic variability in strains isolated from Japanese children during 1983-2003. Tanaka, K., Numazaki, K., Tsutsumi, H. J. Med. Virol. (2005) [Pubmed]
  9. Human cytomegalovirus UL144 open reading frame: sequence hypervariability in low-passage clinical isolates. Lurain, N.S., Kapell, K.S., Huang, D.D., Short, J.A., Paintsil, J., Winkfield, E., Benedict, C.A., Ware, C.F., Bremer, J.W. J. Virol. (1999) [Pubmed]
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