Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CFHR2 - complement factor H-related 2

Homo sapiens

Synonyms: CFHL2, Complement factor H-related protein 2, DDESK59, FHR-2, FHR2, ...

Skerka, C. et al., Yu, D. et al., McRae, J.L. et al.

McRae, Murphy, Eyre, Sutherland, Crawford, Cowan,

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Disease relevance of CFHR2

Compound 20 showed potent anti-HIV activity with EC50 values of 0.0085 microM against NL4-3, 0.021 microM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 microM against FHR-2 (an HIV strain resistant to 8) [1].

High impact information on CFHR2

The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene [2].
The human factor H-related gene 2 (FHR2) encodes a serum protein structurally and immunologically related to complement factor H. We describe the isolation and genomic organization of the human FHR2 gene from a yeast artificial chromosome library [2].
The FHR2 gene is organized in five exons and spans about 7 kilobases (kb) of human genomic DNA [2].
Thus, the three structurally related genes FXIIIb, FHR2, and factor H are linked on human chromosome 1 in the regulators of complement activation (RCA) gene cluster [2].
Analysis of the genomic sequence indicates that the FHR-5 gene is situated between FHR-2 and the non-complement protein factor XIIIb (Fl3B) [3].

References

Anti-AIDS agents 69. moronic acid and other triterpene derivatives as novel potent anti-HIV agents. Yu, D., Sakurai, Y., Chen, C.H., Chang, F.R., Huang, L., Kashiwada, Y., Lee, K.H. J. Med. Chem. (2006) [Pubmed]
The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene. Skerka, C., Moulds, J.M., Taillon-Miller, P., Hourcade, D., Zipfel, P.F. Immunogenetics (1995) [Pubmed]
Location and structure of the human FHR-5 gene. McRae, J.L., Murphy, B.E., Eyre, H.J., Sutherland, G.R., Crawford, J., Cowan, P.J. Genetica (2002) [Pubmed]

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