Disease relevance of Coagulation factor xiiib

• However, a moderate reduction in the plasma level of the functional subunit (factor XIIIA) and also to a lesser extent of the carrier subunit (factor XIIIB), and a decrease in the XIIIA:B subunit ratio, have recently been reported in patients with the inflammatory bowel disorder Crohn's disease, particularly during clinical relapse [1].
• Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins [2].

High impact information on Coagulation factor xiiib

• Genetic studies of low abundance human plasma proteins. II. Population genetics of coagulation factor XIIIB [3].
• The adhesive activity of factor XIIIa was not dependent on the transglutaminase activity, and did not involve the factor XIIIb-subunits [4].
• Factor XIIIA is secreted as a monomer into the extracellular matrix of the theca externa and is not associated with factor XIIIB as is the case in plasma [5].
• Analysis of the genetic polymorphism of coagulation factor XIIIB (FXIIIB) by isoelectric focusing [6].
• To determine the relative importance of various sites on these autoxidation products toward alkylation we have rationally designed and synthesized 4-Me-5,6-DHT (16a), 7-Me-5,6-DHT (16b), and 4,7-Me2-5,6-DHT (16c) [7].

Biological context of Coagulation factor xiiib

• Phenotypes of factor XIIIB subunit were essentially classified into three common patterns A, B and AB [8].
• Total lod scores excluded linkage of CMT1 to LR67 and to DR10 at 5 cM or less, to DR78 at 10 cM or less, alpha-spectrin at 15 cM or less and Factor XIIIB at 20 cM or less [9].
• This probe, as well as 4 other known chromosome 1 markers, alpha-spectrin, Factor XIIIB, DR10 and DR78, were used for linkage studies in 15 Charcot-Marie-Tooth disease (CMT1) families [9].
• A population study was carried out on 301 ethnic Germans from Düsseldorf (Northrhine Westphalia) using the short tandem repeat (STR) system HumF13B (Coagulation Factor XIIIB) [10].
• The factor XIIIB gene was examined to determine the nature of a previously described 300 bp restriction fragment length polymorphism (RFLP) seen in the human population [11].

Gene context of Coagulation factor xiiib

• Linkage data on human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B) are presented [12].
• Linkage analyses of human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B) [12].
• The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene [13].
• Polymerase chain reaction analysis of different regions within the factor XIIIB gene was carried out to define a high resolution map of the region encompassing the polymorphism, followed by DNA sequence analysis [11].

Analytical, diagnostic and therapeutic context of Coagulation factor xiiib

• The genetic variants of the coagulation factor XIIIB (FXIIIB) were analyzed by isoelectric focusing, carried out in agarose gels and followed by immunofixation [6].
• There were no significant differences between the ELISA and electroimmunodiffusion assays either for factor XIIIA (means +/- 1 standard deviation 95 +/- 15.9 and 89 +/- 22.7 respectively) or for factor XIIIB (99 +/- 18.3 and 106 +/- 23.4 respectively) [1].

References