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Chemical Compound Review

AC1Q6XFP     3-(2-aminoethyl)-4-methyl-1H- indole-5,6...

Synonyms: CTK8D5702, AR-1E6112, AC1L2PV2, 4-Me-5,6-Dht, 97073-66-0
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Disease relevance of Coagulation factor xiiib

  • However, a moderate reduction in the plasma level of the functional subunit (factor XIIIA) and also to a lesser extent of the carrier subunit (factor XIIIB), and a decrease in the XIIIA:B subunit ratio, have recently been reported in patients with the inflammatory bowel disorder Crohn's disease, particularly during clinical relapse [1].
  • Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins [2].

High impact information on Coagulation factor xiiib


Biological context of Coagulation factor xiiib


Gene context of Coagulation factor xiiib


Analytical, diagnostic and therapeutic context of Coagulation factor xiiib

  • The genetic variants of the coagulation factor XIIIB (FXIIIB) were analyzed by isoelectric focusing, carried out in agarose gels and followed by immunofixation [6].
  • There were no significant differences between the ELISA and electroimmunodiffusion assays either for factor XIIIA (means +/- 1 standard deviation 95 +/- 15.9 and 89 +/- 22.7 respectively) or for factor XIIIB (99 +/- 18.3 and 106 +/- 23.4 respectively) [1].


  1. Development and evaluation of ELISAs for factor XIIIA and XIIIB subunits in plasma. Murdock, P.J., Owens, D.L., Chitolie, A., Hutton, R.A., Lee, C.A. Thromb. Res. (1992) [Pubmed]
  2. Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins. Mizutani, K., Nishimukai, H., Yasugi, T., Iwahashi, K., Tsunekawa, K., Shinomiya, T. Hum. Hered. (1991) [Pubmed]
  3. Genetic studies of low abundance human plasma proteins. II. Population genetics of coagulation factor XIIIB. Kamboh, M.I., Ferrell, R.E. Am. J. Hum. Genet. (1986) [Pubmed]
  4. Factor XIIIa supports microvascular endothelial cell adhesion and inhibits capillary tube formation in fibrin. Dallabrida, S.M., Falls, L.A., Farrell, D.H. Blood (2000) [Pubmed]
  5. Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wall. Recheis, B., Osanger, A., Haubenwallner, S., Schneider, W.J., Nimpf, J. J. Biol. Chem. (2000) [Pubmed]
  6. Analysis of the genetic polymorphism of coagulation factor XIIIB (FXIIIB) by isoelectric focusing. Leifheit, H.J., Cleve, H. Electrophoresis (1988) [Pubmed]
  7. Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines. Sinhababu, A.K., Ghosh, A.K., Borchardt, R.T. J. Med. Chem. (1985) [Pubmed]
  8. Genetic polymorphism of coagulation factor XIIIB subunit in Japanese. Nakamura, S., Abe, K. Ann. Hum. Genet. (1982) [Pubmed]
  9. Isolation and use of chromosome 1 probes for linkage studies on Charcot-Marie-Tooth disease. Griffiths, L.R., Zwi, M.B., Mesterovic, N., Ross, D.A., Board, P.G., Callen, D.F., Mohandas, T., Buckland, R., Fletcher, J.M., Driesel, A.J. Ann. Hum. Genet. (1990) [Pubmed]
  10. Northrhine Westphalian data on the locus F13B. Huckenbeck, W., Scheil, H.G., Kaiser, A., Stancu, V., Bonte, W. Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur. (1996) [Pubmed]
  11. Identification of a human specific Alu insertion in the factor XIIIB gene. Kass, D.H., Aleman, C., Batzer, M.A., Deininger, P.L. Genetica (1994) [Pubmed]
  12. Linkage analyses of human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B). Kömpf, J., Luckenbach, C., Kloor, D., Krczal, D., Amorim, A., Ritter, H. Hum. Genet. (1989) [Pubmed]
  13. The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene. Skerka, C., Moulds, J.M., Taillon-Miller, P., Hourcade, D., Zipfel, P.F. Immunogenetics (1995) [Pubmed]
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