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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Wee1  -  WEE1 G2 checkpoint kinase

Rattus norvegicus

Synonyms: Wee1-like protein kinase, Wee1A kinase
 
 
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High impact information on Wee1

  • Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis [1].
  • This checkpoint involves inhibitory phosphorylation of Cdc2 at the tyrosine-15 (Y15) position, mediated in part by the Wee1 protein kinase [1].
  • Under conditions of either growth arrest or apoptosis, p53 activation resulted in the down-regulation of Wee1 expression and dephosphorylation of Cdc2 [1].
  • Since Wee1i, lack of these 214 residues, it may evade this degradation and thus provide constitutive Wee1-like kinase activity to inhibit mitotic cell proliferation [2].
  • Recombinant and partially purified Wee1i from rat thymus displayed kinase activity comparable to or higher than Wee1 [2].

References

  1. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Leach, S.D., Scatena, C.D., Keefer, C.J., Goodman, H.A., Song, S.Y., Yang, L., Pietenpol, J.A. Cancer Res. (1998) [Pubmed]
  2. Identification of a novel Wee1 isoform. Yu, Y., Chen, B., Chen, Z., Fan, C., Han, Y., Zhang, J., He, L., Ingram, A., Kapoor, A., Wang, J.H., Tang, D. Biochim. Biophys. Acta (2005) [Pubmed]
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