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Gene Review

Wee1  -  WEE 1 homolog 1 (S. pombe)

Mus musculus

Synonyms: Wee1-like protein kinase, Wee1A, Wee1A kinase
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Disease relevance of Wee1


High impact information on Wee1

  • Seliciclib induced rhythmic clock gene expression patterns with physiologic phase relations only after ZT3 dosing. c-Myc and Wee1 mRNAs displayed synchronous circadian rhythms in the tumors of control mice receiving vehicle only but not in those of mice given the drug [2].
  • Because Wee1 kinase is crucial in maintaining G(2) arrest through its inhibitory phosphorylation of Cdc2, we developed a high-throughput mass screening assay and used it to screen chemical library for Wee1 inhibitors [3].
  • In line with this observation, the Wee1 tyrosine kinase that negatively controls Cdk1 was less efficiently inactivated during G2 in Int-6-depleted cells [4].
  • (c) Alteration of cyclin G1 and Wee-1 kinase genes may be related to the G2/M arrest induced by benzene exposure [5].
  • Wee1 is a kinase regulator of the M-phase promoting factor (a complex of cdc2 and cyclin B1) [6].

Biological context of Wee1


Anatomical context of Wee1


Associations of Wee1 with chemical compounds

  • The inhibition of p34(cdc2) kinase activity by apigenin treatment correlated with increasing levels of p34(cdc2) phosphorylation at Tyr15, a site in the p34(cdc2) kinase that undergoes inhibitory phosphorylation by Wee1 kinase [8].
  • 5. To study the function of Wee1 further, we have developed MEF cells in which Wee1 is disrupted by a tamoxifen inducible Cre-LoxP approach [7].

Other interactions of Wee1

  • Additionally, we detected significant decreases in the newly isolated CDK inhibitor (CKI) p27kip but not Wee 1 kinase [9].

Analytical, diagnostic and therapeutic context of Wee1


  1. Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. Hashimoto, O., Shinkawa, M., Torimura, T., Nakamura, T., Selvendiran, K., Sakamoto, M., Koga, H., Ueno, T., Sata, M. BMC Cancer (2006) [Pubmed]
  2. Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor. Iurisci, I., Filipski, E., Reinhardt, J., Bach, S., Gianella-Borradori, A., Iacobelli, S., Meijer, L., L??vi, F. Cancer Res. (2006) [Pubmed]
  3. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Wang, Y., Li, J., Booher, R.N., Kraker, A., Lawrence, T., Leopold, W.R., Sun, Y. Cancer Res. (2001) [Pubmed]
  4. Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation. Morris, C., Jalinot, P. Oncogene (2005) [Pubmed]
  5. Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue. Yoon, B.I., Li, G.X., Kitada, K., Kawasaki, Y., Igarashi, K., Kodama, Y., Inoue, T., Kobayashi, K., Kanno, J., Kim, D.Y., Inoue, T., Hirabayashi, Y. Environ. Health Perspect. (2003) [Pubmed]
  6. Expression of wee1 and its related cell cycle components in mouse early stage follicles. Park, C.E., Kim, Y.H., Jeon, E.H., Cha, K.Y., Lee, S.H., Lee, K.A. Cells Tissues Organs (Print) (2004) [Pubmed]
  7. Murine wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Tominaga, Y., Li, C., Wang, R.H., Deng, C.X. Int. J. Biol. Sci. (2006) [Pubmed]
  8. A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. McVean, M., Weinberg, W.C., Pelling, J.C. Mol. Carcinog. (2002) [Pubmed]
  9. Cell cycle control in isoproterenol-induced murine salivary acinar cell proliferation. Zeng, T., Yamamoto, H., Bowen, E., Broverman, R.L., Nguyen, K.H., Humphreys-Beher, M.G. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1996) [Pubmed]
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