Gene Review:
WEE1 - WEE1 G2 checkpoint kinase
Homo sapiens
Synonyms:
WEE1A, WEE1hu, Wee1-like protein kinase, Wee1A kinase
- Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Parker, L.L., Piwnica-Worms, H. Science (1992)
- Cell cycle regulation of human WEE1. McGowan, C.H., Russell, P. EMBO J. (1995)
- Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. Parker, L.L., Sylvestre, P.J., Byrnes, M.J., Liu, F., Piwnica-Worms, H. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Requirement of p34cdc2 kinase for apoptosis mediated by the Fas/APO-1 receptor and interleukin 1beta-converting enzyme-related proteases. Yao, S.L., McKenna, K.A., Sharkis, S.J., Bedi, A. Cancer Res. (1996)
- Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. Wang, F., Zhu, Y., Huang, Y., McAvoy, S., Johnson, W.B., Cheung, T.H., Chung, T.K., Lo, K.W., Yim, S.F., Yu, M.M., Ngan, H.Y., Wong, Y.F., Smith, D.I. Oncogene (2005)
- WEE1-like CDK tyrosine kinase mRNA level is regulated temporally and spatially in sea urchin embryos. Nemer, M., Stuebing, E.W. Mech. Dev. (1996)
- Role of tyrosine phosphorylation in radiation-induced cell cycle-arrest of leukemic B-cell precursors at the G2-M transition checkpoint. Tuel-Ahlgren, L., Jun, X., Waddick, K.G., Jin, J., Bolen, J., Uckun, F.M. Leuk. Lymphoma (1996)
- Construction and co-expression of bicistronic plasmid encoding human WEE1 and stem cell factor. Lei, P., Li, W.H., Liao, W.J., Yu, B., Zhu, H.F., Shao, J.F., Shen, G.X. Acta Biochim. Biophys. Sin. (Shanghai) (2005)
- Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor. Li, J., Wang, Y., Sun, Y., Lawrence, T.S. Radiat. Res. (2002)
- Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. Taviaux, S.A., Demaille, J.G. Genomics (1993)
- Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cichutek, A., Brueckmann, T., Seipel, B., Hauser, H., Schlaubitz, S., Prawitt, D., Hankeln, T., Schmidt, E.R., Winterpacht, A., Zabel, B.U. Cytogenet. Cell Genet. (2001)
- Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Wood, P.A., Du-Quiton, J., You, S., Hrushesky, W.J. Mol. Cancer Ther. (2006)