Disease relevance of egr

• In support of this model, we show that mutations in the fly gene eiger, a TNF homolog, delay the lethality of Salmonella infection [1].

High impact information on egr

• Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila [2].
• This compensatory mechanism has been referred to as 'telophase rescue'. We demonstrate that the Drosophila homolog of the mammalian tumor-necrosis factor (TNF) receptor-associated factor (DTRAF1) and Eiger (Egr), the homolog of the mammalian TNF, are required for telophase rescue of Mira/Pros [3].
• Genetic evidence shows that Eiger induces cell death by activating the Drosophila JNK pathway [4].
• The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal cells to which muscles attach during late stages of embryogenesis [5].
• The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference [6].

Biological context of egr

• A single TNF family member, Eiger, is encoded in the Drosophila genome, offering the possibility of applying genetic approaches for pursuing this goal [7].
• In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death [4].
• Like a subset of mammalian TNF proteins, Eiger is a potent inducer of apoptosis [8].
• Both Eiger and Wengen are expressed in distinctive patterns during embryogenesis and Eiger is responsive to genotoxic stress [9].

Associations of egr with chemical compounds

• Our results illustrate that Eiger and Wengen represent proximal components of an evolutionarily conserved TNF-like signaling pathway in Drosophila [9].
• Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in aSalmonella-Infected Fruit Fly [1].

Regulatory relationships of egr

• Thus, in contrast to morphogenetic processes, such as dorsal closure of the embryo, in which the JNK pathway is activated by the JNKKK Slipper, Eiger uses the dTAB2-dTAK1 module to induce JNK signaling activity [7].

Other interactions of egr

• In a large-scale screen the Drosophila homolog of TAB2/3 (dTAB2) was identified as an essential component of the Eiger-JNK pathway [7].
• Unlike its mammalian counterparts, however, the apoptotic effect of Eiger does not require the activity of the caspase-8 homolog DREDD, but it completely depends on its ability to activate the JNK pathway [8].

References