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Gene Review

egr  -  eiger

Drosophila melanogaster

Synonyms: BcDNA:RH51659, CG12919, Dmel\CG12919, Ect1, Egr, ...
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Disease relevance of egr

  • In support of this model, we show that mutations in the fly gene eiger, a TNF homolog, delay the lethality of Salmonella infection [1].

High impact information on egr


Biological context of egr


Associations of egr with chemical compounds

  • Our results illustrate that Eiger and Wengen represent proximal components of an evolutionarily conserved TNF-like signaling pathway in Drosophila [9].
  • Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in aSalmonella-Infected Fruit Fly [1].

Regulatory relationships of egr

  • Thus, in contrast to morphogenetic processes, such as dorsal closure of the embryo, in which the JNK pathway is activated by the JNKKK Slipper, Eiger uses the dTAB2-dTAK1 module to induce JNK signaling activity [7].

Other interactions of egr

  • In a large-scale screen the Drosophila homolog of TAB2/3 (dTAB2) was identified as an essential component of the Eiger-JNK pathway [7].
  • Unlike its mammalian counterparts, however, the apoptotic effect of Eiger does not require the activity of the caspase-8 homolog DREDD, but it completely depends on its ability to activate the JNK pathway [8].


  1. Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in aSalmonella-Infected Fruit Fly. Brandt, S.M., Dionne, M.S., Khush, R.S., Pham, L.N., Vigdal, T.J., Schneider, D.S. PLoS Biol. (2004) [Pubmed]
  2. Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila. Brönner, G., Chu-LaGraff, Q., Doe, C.Q., Cohen, B., Weigel, D., Taubert, H., Jäckle, H. Nature (1994) [Pubmed]
  3. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. Wang, H., Cai, Y., Chia, W., Yang, X. EMBO J. (2006) [Pubmed]
  4. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. Igaki, T., Kanda, H., Yamamoto-Goto, Y., Kanuka, H., Kuranaga, E., Aigaki, T., Miura, M. EMBO J. (2002) [Pubmed]
  5. Epidermal muscle attachment site-specific target gene expression and interference with myotube guidance in response to ectopic stripe expression in the developing Drosophila epidermis. Vorbrüggen, G., Jäckle, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. Kanda, H., Igaki, T., Kanuka, H., Yagi, T., Miura, M. J. Biol. Chem. (2002) [Pubmed]
  7. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Geuking, P., Narasimamurthy, R., Basler, K. Genetics (2005) [Pubmed]
  8. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Moreno, E., Yan, M., Basler, K. Curr. Biol. (2002) [Pubmed]
  9. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Kauppila, S., Maaty, W.S., Chen, P., Tomar, R.S., Eby, M.T., Chapo, J., Chew, S., Rathore, N., Zachariah, S., Sinha, S.K., Abrams, J.M., Chaudhary, P.M. Oncogene (2003) [Pubmed]
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