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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Fadd  -  Fas-associated death domain ortholog

Drosophila melanogaster

Synonyms: BG4, BG4_DROME, CG12297, Death domain-containing adapter protein BG4, Dmel\CG12297, ...
 
 
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Disease relevance of BG4

  • Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria [1].
  • Using inducible expression of dFADD double-stranded RNA, we demonstrate that dFADD is a novel component of the Imd pathway: dFADD double-stranded RNA expression reduces the induction of antibacterial peptide-encoding genes after infection and renders the fly susceptible to Gram-negative bacterial infection [2].
 

High impact information on BG4

  • Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD [1].
  • We also show that dMyD88 associates with the death domain-containing adapter Drosophila Fas-associated death domain-containing protein (dFADD), which in turn interacts with the apical caspase Dredd [3].
  • Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line [4].
  • Epistatic studies indicate that dFADD acts between Imd and Dredd [2].
  • dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD [5].
 

Biological context of BG4

  • The structural and functional similarities between dFADD and FADD suggest the existence of a FADD-like apoptosis pathway in Drosophila [5].

References

  1. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Naitza, S., Rossé, C., Kappler, C., Georgel, P., Belvin, M., Gubb, D., Camonis, J., Hoffmann, J.A., Reichhart, J.M. Immunity (2002) [Pubmed]
  2. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Leulier, F., Vidal, S., Saigo, K., Ueda, R., Lemaitre, B. Curr. Biol. (2002) [Pubmed]
  3. Drosophila MyD88 is an adapter in the Toll signaling pathway. Horng, T., Medzhitov, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line. Vucic, D., Seshagiri, S., Miller, L.K. Mol. Cell. Biol. (1997) [Pubmed]
  5. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. Hu, S., Yang, X. J. Biol. Chem. (2000) [Pubmed]
 
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