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Gene Review:

ZBTB48 - zinc finger and BTB domain containing 48

Homo sapiens

Synonyms: HKR3, Krueppel-related zinc finger protein 3, Protein HKR3, ZNF855, Zinc finger and BTB domain-containing protein 48, ...

Maris, J.M. et al., Maris, J.M. et al.

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Disease relevance of ZBTB48

Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene [1]?

High impact information on ZBTB48

Human Krüppel-related 3 (HKR3) is a zinc finger gene that maps within chromosome subbands 1p36.2-.3, a region postulated to contain a tumour suppressor gene associated with advanced neuroblastomas [1].
We conclude that HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in neuroblastoma and other human cancers [1].
Hemizygous deletion of HKR3 in a lymphoblastoid cell line derived from a neuroblastoma patient with a constitutional 1p36 interstitial deletion and in the neuroblastoma cell line SK-N-AS, which also has a small interstitial 1p36 deletion, has been observed [1].
Genomic clones of HKR3 were isolated from a P1 library and localized to human chromosome subband 1p36.3 by human-rodent somatic cell hybrid mapping and fluorescence in situ hybridization [2].
HKR3 spans 9.5 kb of genomic DNA and is contained in 11 exons [2].

Biological context of ZBTB48

We report the cloning, mapping, and characterization of the zinc finger gene Human Krüppel-Related 3 (HKR3) [2].
HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in human cancers [2].

References

Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene? Maris, J.M., Jensen, J., Sulman, E.P., Beltinger, C.P., Allen, C., Biegel, J.A., Brodeur, G.M., White, P.S. Eur. J. Cancer (1997) [Pubmed]
Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3. Maris, J.M., Jensen, S.J., Sulman, E.P., Beltinger, C.P., Gates, K., Allen, C., Biegel, J.A., Brodeur, G.M., White, P.S. Genomics (1996) [Pubmed]

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