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Gene Review

CDC45L  -  CG3658 gene product from transcript CG3658-RA

Drosophila melanogaster

Synonyms: CDC45, CG3658, Cdc45, DmCdc45, Dmel\CG3658, ...
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High impact information on CDC45L

  • To study Cdc45's function in DNA replication, we purified Cdc45 protein from Drosophila embryo extracts by a combination of traditional and immunoaffinity chromatography steps and found that the protein exists in a stable, high-molecular-weight complex with the Mcm2-7 hexamer and the GINS tetramer [1].
  • RNA interference knock-down experiments targeting the GINS and Cdc45 components establish that the proteins are required for the S phase transition in Drosophila cells [1].
  • Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification [2].


  1. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Moyer, S.E., Lewis, P.W., Botchan, M.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification. Loebel, D., Huikeshoven, H., Cotterill, S. Nucleic Acids Res. (2000) [Pubmed]
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