Gene Review:
CDC45 - cell division cycle 45
Homo sapiens
Synonyms:
CDC45L, CDC45L2, Cell division control protein 45 homolog, PORC-PI-1, UNQ374/PRO710
- The human homolog of Saccharomyces cerevisiae CDC45. Saha, P., Thome, K.C., Yamaguchi, R., Hou, Z., Weremowicz, S., Dutta, A. J. Biol. Chem. (1998)
- Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. Shaikh, T.H., Gottlieb, S., Sellinger, B., Chen, F., Roe, B.A., Oakey, R.J., Emanuel, B.S., Budarf, M.L. Mamm. Genome (1999)
- Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression. Sheu, Y.J., Stillman, B. Mol. Cell (2006)
- Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Alderton, G.K., Galbiati, L., Griffith, E., Surinya, K.H., Neitzel, H., Jackson, A.P., Jeggo, P.A., O'Driscoll, M. Nat. Cell Biol. (2006)
- GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Gambus, A., Jones, R.C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R.D., Labib, K. Nat. Cell Biol. (2006)
- Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. Yabuuchi, H., Yamada, Y., Uchida, T., Sunathvanichkul, T., Nakagawa, T., Masukata, H. EMBO J. (2006)
- Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. Kukimoto, I., Igaki, H., Kanda, T. Eur. J. Biochem. (1999)
- Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Syljuåsen, R.G., Sørensen, C.S., Hansen, L.T., Fugger, K., Lundin, C., Johansson, F., Helleday, T., Sehested, M., Lukas, J., Bartek, J. Mol. Cell. Biol. (2005)
- The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism. Liu, P., Barkley, L.R., Day, T., Bi, X., Slater, D.M., Alexandrow, M.G., Nasheuer, H.P., Vaziri, C. J. Biol. Chem. (2006)
- The CLDN5 locus may be involved in the vulnerability to schizophrenia. Sun, Z.Y., Wei, J., Xie, L., Shen, Y., Liu, S.Z., Ju, G.Z., Shi, J.P., Yu, Y.Q., Zhang, X., Xu, Q., Hemmings, G.P. Eur. Psychiatry (2004)
- UFD1L and CDC45L: a role in DiGeorge syndrome and related phenotypes? Novelli, G., Amati, F., Dallapiccola, B. Trends Genet. (1999)
- Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation. Alexandrow, M.G., Hamlin, J.L. J. Cell Biol. (2005)