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Gene Review

trr  -  trithorax-related

Drosophila melanogaster

Synonyms: CG3848, Dmel\CG3848, EG:63B12.3, Histone-lysine N-methyltransferase trr, KMT2C, ...
 
 
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High impact information on trr

  • In utero rearrangements in the trithorax-related oncogene in infant leukaemias [1].
  • However, preliminary genetic analysis of a trr null allele suggests that TRR protein may not be involved in regulation of homeotic genes (i.e. not a member of the trithorax or Polycomb groups) or in position effect variegation [2].
  • Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein [2].
  • Mutations in trr interact in eye development with EcR, and EcR and TRR can be co-immunoprecipitated on ecdysone treatment [3].
  • Here we report that TRR is a histone methyltransferases capable of trimethylating lysine 4 of histone H3 (H3-K4). trr acts upstream of hedgehog (hh) in progression of the morphogenetic furrow, and is required for retinal differentiation [3].
 

Biological context of trr

References

  1. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Ford, A.M., Ridge, S.A., Cabrera, M.E., Mahmoud, H., Steel, C.M., Chan, L.C., Greaves, M. Nature (1993) [Pubmed]
  2. Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein. Sedkov, Y., Benes, J.J., Berger, J.R., Riker, K.M., Tillib, S., Jones, R.S., Mazo, A. Mech. Dev. (1999) [Pubmed]
  3. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Sedkov, Y., Cho, E., Petruk, S., Cherbas, L., Smith, S.T., Jones, R.S., Cherbas, P., Canaani, E., Jaynes, J.B., Mazo, A. Nature (2003) [Pubmed]
 
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