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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In utero rearrangements in the trithorax-related oncogene in infant leukaemias.

The majority (approximately 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several partner chromosomes. The gene at 11q23 (named MLL, ALL-1, HRX or HTRX-1; refs 2-6) has been cloned and shares homology with the Drosophila developmental gene trithorax. Rearrangements of this gene (called HRX here) occur in introns and cluster in a region of approximately 10 kb; individual patients have different breakpoints. Here we describe three pairs of infant twins with concordant leukaemia who each share unique (clonal) but non-constitutive HRX rearrangements in their leukaemic cells, providing evidence that the leukaemogenic event originates in utero and unequivocal support for the intra-placental 'metastasis' hypothesis for leukaemia concordance in twins.[1]


  1. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Ford, A.M., Ridge, S.A., Cabrera, M.E., Mahmoud, H., Steel, C.M., Chan, L.C., Greaves, M. Nature (1993) [Pubmed]
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