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Gene Review:

proA - zinc metalloproteinase precursor

Legionella pneumophila str. Paris

Moffat, J.F. et al., Moffat, J.F. et al.

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Disease relevance of proA

To determine the effects, if any, of the Zn-metalloprotease on virulence of Legionella pneumophila infection, an isogenic mutant deficient in protease (encoded by the proA gene) was tested in an Acanthamoeba cell model, in guinea-pig macrophages, and in a guinea-pig pneumonia model [1].

High impact information on proA

The proA gene was found to be expressed in L. pneumophila during intracellular growth in amoebae by measuring the light produced from a truncated luxC gene fusion with the proA promoter [1].
TnphoA fusions indicated that the entire proA open reading frame was transcribed and translated, including the 5' leader sequence [2].

References

Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model. Moffat, J.F., Edelstein, P.H., Regula, D.P., Cirillo, J.D., Tompkins, L.S. Mol. Microbiol. (1994) [Pubmed]
Further molecular characterization of the cloned Legionella pneumophila zinc metalloprotease. Moffat, J.F., Black, W.J., Tompkins, L.S. Infect. Immun. (1994) [Pubmed]

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