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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Abcg2  -  ATP-binding cassette, subfamily G (WHITE),...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family G member 2, Bcrp1, Breast cancer resistance protein 1 homolog, Urate exporter
 
 
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Disease relevance of Abcg2

 

High impact information on Abcg2

  • Therefore, Bcrp1 has an important role in extruding glucuronide and sulfate conjugates formed in enterocytes into the intestinal lumen, whereas Mrp2 is responsible for the efflux of some glucuronide conjugates [1].
  • The intestinal lumen of EHBRs and Bcrp1 (-/-) mice was perfused with medium containing 4-methylumbelliferone (4MU) and E3040 [6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridilmethyl) benzothiazole] to determine the efflux of metabolites into the outflow [1].
  • Immunocytochemical analysis demonstrates specificity of expression of Sox1, ABCG2/Bcrp1, and shows that nucleostemin labels both progenitor and stem cell populations [2].

References

  1. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Adachi, Y., Suzuki, H., Schinkel, A.H., Sugiyama, Y. Mol. Pharmacol. (2005) [Pubmed]
  2. Membrane properties of rat embryonic multipotent neural stem cells. Cai, J., Cheng, A., Luo, Y., Lu, C., Mattson, M.P., Rao, M.S., Furukawa, K. J. Neurochem. (2004) [Pubmed]
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