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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADP1  -  putative ATP-dependent permease ADP1

Saccharomyces cerevisiae S288c

Synonyms: YCR011C, YCR105, YCR11C
 
 
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Disease relevance of ADP1

  • Acinetobacter calcoaceticus ADP1 accumulates wax esters and TAGs as intracellular storage lipids [1].
  • Heterologous expression of WS/DGAT from A. calcoaceticus ADP1 in S. cerevisiae H1246 restored TAG but not steryl ester biosynthesis, although high levels of ASAT activity could be demonstrated for WS/DGAT expressed in Escherichia coli XL1-Blue in radiometric in vitro assays with cholesterol and ergosterol as substrates [2].
 

High impact information on ADP1

  • ABCP, white, and ADP1 all have a single ATP-binding domain at the NH2 terminus and a single COOH-terminal set of transmembrane segments [3].
  • The bifunctional wax ester synthase/acyl-coenzyme A:diacylglycerol acyltransferase (WS/DGAT) is the key enzyme in storage lipid accumulation in the gram-negative bacterium Acinetobacter calcoaceticus ADP1, mediating wax ester, and to a lesser extent, triacylglycerol (TAG) biosynthesis [2].
  • YCR105 is immediately centromere proximal to the PGK gene (opposite strand) on the right arm of chromosome III about 20 kb from the centromere [4].
  • The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases [4].

References

  1. A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1. Kalscheuer, R., Steinbüchel, A. J. Biol. Chem. (2003) [Pubmed]
  2. Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase. Kalscheuer, R., Luftmann, H., Steinbüchel, A. Appl. Environ. Microbiol. (2004) [Pubmed]
  3. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Allikmets, R., Schriml, L.M., Hutchinson, A., Romano-Spica, V., Dean, M. Cancer Res. (1998) [Pubmed]
  4. The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases. Purnelle, B., Skala, J., Goffeau, A. Yeast (1991) [Pubmed]
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