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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HLA-DRB5  -  major histocompatibility complex, class II...

Homo sapiens

Synonyms: DR beta-5, DR2-beta-2, Dw2, HLA class II histocompatibility antigen, DR beta 5 chain, MHC class II antigen DRB5
 
 
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High impact information on HLA-DRB5

  • A new HLA-DRB5 allele, HLA-DRB5*0113, has been identified in an Italian patient during routine HLA typing in order to activate a bone marrow donor search [1].
  • Of the three DRB genes, two are presumably functional (HLA-DRB1 and HLA-DRB5), whereas the third (HLA-DRBVI) is a pseudogene [2].
 

Anatomical context of HLA-DRB5

  • We report here the exon 2 sequence of a new HLA-DRB5 allele, DRB5*0106, that was identified in two volunteer bone marrow donors from the Swiss national registry [3].

References

  1. Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniquesdagger. Garino, E., Berrino, M., Bertinetto, F., Caropreso, P., Chidichimo, R., Dametto, E., Fasano, M.E., Frisaldi, E., Mazzola, G., Tondat, F., Boccadoro, M., Bruno, B., Amoroso, A. Tissue Antigens (2006) [Pubmed]
  2. Primate DRB6 pseudogenes: clue to the evolutionary origin of the HLA-DR2 haplotype. Figueroa, F., O'hUigin, C., Inoki, H., Klein, J. Immunogenetics (1991) [Pubmed]
  3. Sequence of a new HLA-DR allele, DRB5*0106. Kervaire, B., Tiercy, J.M. Eur. J. Immunogenet. (1997) [Pubmed]
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