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Gene Review

hay  -  haywire

Drosophila melanogaster

Synonyms: ATP-dependent DNA helicase hay, CG8019, DNA excision repair protein haywire, DhR25, DhXPB, ...
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Disease relevance of hay

  • The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS) [1].

High impact information on hay


Biological context of hay


Anatomical context of hay

  • We found that the TFIIH core is initially located in the cytoplasm of syncytial blastoderm embryos, and that after mitotic division ten and until the cellular blastoderm stage, the core moves from the cytoplasm to the nucleus [8].
  • These phenotypes are consistent with a role for the haywire gene product in general microtubule function [3].

Physical interactions of hay


Regulatory relationships of hay


Other interactions of hay


  1. A Drosophila model for xeroderma pigmentosum and Cockayne's syndrome: haywire encodes the fly homolog of ERCC3, a human excision repair gene. Mounkes, L.C., Jones, R.S., Liang, B.C., Gelbart, W., Fuller, M.T. Cell (1992) [Pubmed]
  2. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Larochelle, S., Pandur, J., Fisher, R.P., Salz, H.K., Suter, B. Genes Dev. (1998) [Pubmed]
  3. Interacting genes that affect microtubule function: the nc2 allele of the haywire locus fails to complement mutations in the testis-specific beta-tubulin gene of Drosophila. Regan, C.L., Fuller, M.T. Genes Dev. (1988) [Pubmed]
  4. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. Larochelle, S., Chen, J., Knights, R., Pandur, J., Morcillo, P., Erdjument-Bromage, H., Tempst, P., Suter, B., Fisher, R.P. EMBO J. (2001) [Pubmed]
  5. Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo. Schwartz, B.E., Larochelle, S., Suter, B., Lis, J.T. Mol. Cell. Biol. (2003) [Pubmed]
  6. RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila. Gutiérrez, L., Merino, C., Vázquez, M., Reynaud, E., Zurita, M. Genesis (2004) [Pubmed]
  7. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen, J., Larochelle, S., Li, X., Suter, B. Nature (2003) [Pubmed]
  8. TFIIH trafficking and its nuclear assembly during early Drosophila embryo development. Aguilar-Fuentes, J., Valadez-Graham, V., Reynaud, E., Zurita, M. J. Cell. Sci. (2006) [Pubmed]
  9. Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos. Leclerc, V., Raisin, S., Léopold, P. EMBO J. (2000) [Pubmed]
  10. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Fregoso, M., Lainé, J.P., Aguilar-Fuentes, J., Mocquet, V., Reynaud, E., Coin, F., Egly, J.M., Zurita, M. Mol. Cell. Biol. (2007) [Pubmed]
  11. Molecular characterization of mutant alleles of the DNA repair/basal transcription factor haywire/ERCC3 in Drosophila. Mounkes, L.C., Fuller, M.T. Genetics (1999) [Pubmed]
  12. Interacting genes that affect microtubule function in Drosophila melanogaster: two classes of mutation revert the failure to complement between haync2 and mutations in tubulin genes. Regan, C.L., Fuller, M.T. Genetics (1990) [Pubmed]
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