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Gene Review

Xpd  -  Xeroderma pigmentosum D ortholog (H. sapiens)

Drosophila melanogaster

Synonyms: CG9433, DhR3, DhXPD, DmXPD, Dmel\CG9433, ...
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Disease relevance of Xpd

  • Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog [1].
  • Mutations in the XPD gene generate the cancer-prone syndrome xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy [1].

High impact information on Xpd

  • Distribution analysis in polytene chromosomes shows that DmXPD is highly concentrated in the interbands, especially in the highly transcribed regions known as puffs [2].
  • In embryos at the syncytial blastoderm stage, DmXPD is cytoplasmic [2].
  • UV-light irradiation of third-instar larvae induces an increase in the signal intensity and in the number of sites where the DmXPD protein is located in polytene chromosomes, indicating that the DmXPD protein is recruited intensively in the chromosomes as a response to DNA damage [2].
  • At the onset of transcription in somatic cells and during gastrulation in germ cells, DmXPD moves to the nuclei [2].
  • In addition, we present evidence that suggests that DNA helicase subunits XPB and XPD are assembled in the core when they are transported into the nucleus and are required for the onset of transcription [3].

Biological context of Xpd


Other interactions of Xpd

  • This is an expected phenotype if the XPD function is affected and indicates that the antisense approach may be an alternative in the study of TFIIH functions in Drosophila [1].


  1. Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog. Sandoval, M.T., Zurita, M. Antisense Nucleic Acid Drug Dev. (2001) [Pubmed]
  2. The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes. Reynaud, E., Lomelí, H., Vázquez, M., Zurita, M. Mol. Biol. Cell (1999) [Pubmed]
  3. TFIIH trafficking and its nuclear assembly during early Drosophila embryo development. Aguilar-Fuentes, J., Valadez-Graham, V., Reynaud, E., Zurita, M. J. Cell. Sci. (2006) [Pubmed]
  4. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen, J., Larochelle, S., Li, X., Suter, B. Nature (2003) [Pubmed]
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