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Gene Review

sws  -  swiss cheese

Drosophila melanogaster

Synonyms: CG2212, DSWS, Dmel\CG2212, Neuropathy target esterase sws, Swiss cheese, ...
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High impact information on sws

  • Transcript analysis of the region that rescues the olfE phenotype has shown one major transcript at 5.4 kb and a minor one at 1.7 kb [1].
  • An olfactory gene olfE, which affects response to benzaldehyde in larvae and adults of Drosophila melanogaster, has been mapped between two breakpoints on the X chromosome [1].
  • Sequencing of two sws alleles shows amino acid substitutions in these two conserved domains [2].
  • Our findings suggest an interaction between the sws protein and beta-integrin in the development and/or functioning of the olfactory system [3].
  • This study provides evidence for the roles of different integrin subunits and the sws product in regulating normal olfactory behavior in Drosophila [3].

Biological context of sws

  • Only one of the mutants obtained in our screening (olfD) resulted in a insensitivity to several different odorants. olfA, olfE and olfC map close together in a small region of the chromosome between 7C and 7D [4].
  • Here, we show that both the fly and mouse SWS proteins can rescue the defects that arise in sws mutant flies, whereas a point mutation in the proposed active site cannot restore SWS function [5].

Anatomical context of sws

  • A 14-kb genomic fragment from this region has been used for germ-line transformation of olfE mutant flies, and in one of three transformant lines obtained, rescue of the olfE phenotype is observed by two separate behavioral assays [1].


  1. Molecular cloning of an olfactory gene from Drosophila melanogaster. Hasan, G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M., Benzer, S. J. Neurosci. (1997) [Pubmed]
  3. Genetic interactions provide evidence for the role of integrins in specifying normal olfactory behavior in Drosophila melanogaster. Ayyub, C., Paranjape, J. J. Neurogenet. (2002) [Pubmed]
  4. Genetics of olfactory behavior in Drosophila melanogaster. Ayyub, C., Paranjape, J., Rodrigues, V., Siddiqi, O. J. Neurogenet. (1990) [Pubmed]
  5. Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. Mühlig-Versen, M., da Cruz, A.B., Tschäpe, J.A., Moser, M., Büttner, R., Athenstaedt, K., Glynn, P., Kretzschmar, D. J. Neurosci. (2005) [Pubmed]
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