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Gene Review

Itgbetanu  -  Integrin betanu subunit

Drosophila melanogaster

Synonyms: Beta[[nu]], CG1762, CT5192, Dmel\CG1762, Integrin beta-nu, ...
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Disease relevance of betaInt-nu


Psychiatry related information on betaInt-nu


High impact information on betaInt-nu


Chemical compound and disease context of betaInt-nu

  • To determine the role of affinity modulation of alpha(V)beta(3), a novel monovalent ligand-mimetic antibody (WOW-1) was created by replacing the heavy chain hypervariable region 3 of PAC1 Fab with a single alpha(V) integrin-binding domain from multivalent adenovirus penton base [1].

Biological context of betaInt-nu


Anatomical context of betaInt-nu


Associations of betaInt-nu with chemical compounds

  • This 255 x 10(3) M(r) polypeptide contains the potential integrin recognition sequence Arg-Gly-Asp (RGD) and 16 repeats of a novel 73-77 amino acid motif [13].
  • The results provide evidence that integrin-talin adhesion complexes are necessary to maintain tracheal terminal branches and luminal organization [14].
  • Furthermore, this activity is calcium-sensitive and is regulated in the EDTA-stabilized conformation of the integrin [15].
  • The leucine substitution by proline was shown to affect a residue, which was precisely conserved in different human, rodent, and drosophila integrin-beta polypeptides, and consequently disrupts the alpha-helix formation of the polypeptide segment as determined by Garnier alpha-helicity plot [16].
  • Integrin-linked kinase (ILK) is a focal adhesion serine/threonine protein kinase that is emerging as a key signaling protein functioning at one of the early convergence points of integrin- and growth factor-signaling pathways [17].

Physical interactions of betaInt-nu

  • We demonstrate that Drosophila PINCH and ILK are complexed in vivo and are coincident at the integrin-rich muscle-attachment sites in embryonic muscle [18].
  • Tensin stabilizes integrin adhesive contacts in Drosophila [19].
  • Integrin mutants interact with bs mutants to increase the frequency of intervein blisters but do not typically enhance vein defects [20].
  • Thus, the struthio gene encodes a putative RNA-binding protein that appears to regulate some aspects of Drosophila integrin functioning [21].

Regulatory relationships of betaInt-nu


Other interactions of betaInt-nu


Analytical, diagnostic and therapeutic context of betaInt-nu

  • We have used the polymerase chain reaction to identify a novel integrin receptor beta subunit in Drosophila melanogaster [29].
  • Time-lapse and transmission electron microscopy analyses suggest that Wb facilitates integrin-dependent contact over a large surface and controls the cellular behavior of the wing cells, including their exploratory filopodial activity [30].
  • Cell culture consisting of Drosophila BG2-c6 cells and laminin revealed its value for the analysis of the integrin-mediated activity of extracellular matrix (Takagi, Y., et al. (1998) Neurosci. Lett. 244, 149-152) [31].
  • Integrin-ligand interactions are now considered to provide physical support for cells in order to maintain cohesion, to permit the generation of traction forces to enable movement, and to organize signalling complexes to modulate differentiation and cell fate [32].
  • By immunoblotting with antibodies raised towards a synthetic peptide corresponding to a part of the cytoplasmic region of the deduced protein sequence, it was shown that the integrin is present in the membrane of the hemocytes [33].


  1. Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. Pampori, N., Hato, T., Stupack, D.G., Aidoudi, S., Cheresh, D.A., Nemerow, G.R., Shattil, S.J. J. Biol. Chem. (1999) [Pubmed]
  2. Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Eble, J.A., Wucherpfennig, K.W., Gauthier, L., Dersch, P., Krukonis, E., Isberg, R.R., Hemler, M.E. Biochemistry (1998) [Pubmed]
  3. Involvement of FAK/Src complex in the processes of Escherichia coli phagocytosis by insect hemocytes. Metheniti, A., Paraskevopoulou, N., Lambropoulou, M., Marmaras, V.J. FEBS Lett. (2001) [Pubmed]
  4. Integrin, a transmembrane glycoprotein complex mediating cell-substratum adhesion. Buck, C.A., Horwitz, A.F. J. Cell Sci. Suppl. (1987) [Pubmed]
  5. Integrin-mediated short-term memory in Drosophila. Grotewiel, M.S., Beck, C.D., Wu, K.H., Zhu, X.R., Davis, R.L. Nature (1998) [Pubmed]
  6. A role for integrin in the formation of sarcomeric cytoarchitecture. Volk, T., Fessler, L.I., Fessler, J.H. Cell (1990) [Pubmed]
  7. Developmentally regulated alternative splicing of Drosophila integrin PS2 alpha transcripts. Brown, N.H., King, D.L., Wilcox, M., Kafatos, F.C. Cell (1989) [Pubmed]
  8. The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Bogaert, T., Brown, N., Wilcox, M. Cell (1987) [Pubmed]
  9. Morphogenesis in the absence of integrins: mutation of both Drosophila beta subunits prevents midgut migration. Devenport, D., Brown, N.H. Development (2004) [Pubmed]
  10. Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Brown, N.H. Matrix Biol. (2000) [Pubmed]
  11. An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton? Brown, N.H. Curr. Opin. Cell Biol. (2000) [Pubmed]
  12. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Nombela-Arrieta, C., Lacalle, R.A., Montoya, M.C., Kunisaki, Y., Megías, D., Marqués, M., Carrera, A.C., Mañes, S., Fukui, Y., Martínez-A, C., Stein, J.V. Immunity (2004) [Pubmed]
  13. Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alpha PS2 beta PS integrins. Fogerty, F.J., Fessler, L.I., Bunch, T.A., Yaron, Y., Parker, C.G., Nelson, R.E., Brower, D.L., Gullberg, D., Fessler, J.H. Development (1994) [Pubmed]
  14. Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. Levi, B.P., Ghabrial, A.S., Krasnow, M.A. Development (2006) [Pubmed]
  15. The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity. O'Neill, S., Robinson, A., Deering, A., Ryan, M., Fitzgerald, D.J., Moran, N. J. Biol. Chem. (2000) [Pubmed]
  16. Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia. Pulkkinen, L., Bruckner-Tuderman, L., August, C., Uitto, J. Am. J. Pathol. (1998) [Pubmed]
  17. Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction. Wu, C. J. Cell. Sci. (1999) [Pubmed]
  18. Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Clark, K.A., McGrail, M., Beckerle, M.C. Development (2003) [Pubmed]
  19. Tensin stabilizes integrin adhesive contacts in Drosophila. Torgler, C.N., Narasimha, M., Knox, A.L., Zervas, C.G., Vernon, M.C., Brown, N.H. Dev. Cell (2004) [Pubmed]
  20. Blistered: a gene required for vein/intervein formation in wings of Drosophila. Fristrom, D., Gotwals, P., Eaton, S., Kornberg, T.B., Sturtevant, M., Bier, E., Fristrom, J.W. Development (1994) [Pubmed]
  21. A novel KH-domain protein mediates cell adhesion processes in Drosophila. Lo, P.C., Frasch, M. Dev. Biol. (1997) [Pubmed]
  22. Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. Martin-Bermudo, M.D. Development (2000) [Pubmed]
  23. The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. Kadrmas, J.L., Smith, M.A., Clark, K.A., Pronovost, S.M., Muster, N., Yates, J.R., Beckerle, M.C. J. Cell Biol. (2004) [Pubmed]
  24. kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin. Gregory, S.L., Brown, N.H. J. Cell Biol. (1998) [Pubmed]
  25. Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. Larouche, K., Leclerc, S., Salesse, C., Guérin, S.L. J. Biol. Chem. (2000) [Pubmed]
  26. Laminin-dependent integrin clustering with tyrosine-phosphorylated molecules in a Drosophila neuronal cell line. Takagi, Y., Ui-Tei, K., Miyake, T., Hirohashi, S. Neurosci. Lett. (1998) [Pubmed]
  27. Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit. Brower, D.L., Bunch, T.A., Mukai, L., Adamson, T.E., Wehrli, M., Lam, S., Friedlander, E., Roote, C.E., Zusman, S. Development (1995) [Pubmed]
  28. Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Murakami, S., Umetsu, D., Maeyama, Y., Sato, M., Yoshida, S., Tabata, T. Development (2007) [Pubmed]
  29. A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster. Yee, G.H., Hynes, R.O. Development (1993) [Pubmed]
  30. Tissue-specific laminin expression facilitates integrin-dependent association of the embryonic wing disc with the trachea in Drosophila. Inoue, Y., Hayashi, S. Dev. Biol. (2007) [Pubmed]
  31. Adhesion-dependent tyrosine phosphorylation of enabled in Drosophila neuronal cell line. Takagi, Y., Ui-Tei, K., Hirohashi, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  32. Integrin structure. Humphries, M.J. Biochem. Soc. Trans. (2000) [Pubmed]
  33. Identification and cloning of an integrin beta subunit from hemocytes of the freshwater crayfish Pacifastacus leniusculus. Holmblad, T., Thörnqvist, P.O., Söderhäll, K., Johansson, M.W. J. Exp. Zool. (1997) [Pubmed]
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