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Gene Review

HNF4G  -  hepatocyte nuclear factor 4, gamma

Homo sapiens

Synonyms: HNF-4-gamma, Hepatocyte nuclear factor 4-gamma, NR2A2, NR2A3, Nuclear receptor subfamily 2 group A member 2
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High impact information on HNF4G


Biological context of HNF4G

  • The new member of the HNF4 subfamily shows highest amino acid identity, similar tissue distribution and syntenous chromosomal localization to the recently described human HNF4gamma (NR2A2), we therefore classify it as mouse HNF4gamma (mHNF4gamma) [4].

Other interactions of HNF4G

  • Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs [5].


  1. No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY. Hara, M., Wang, X., Paz, V.P., Cox, N.J., Iwasaki, N., Ogata, M., Iwamoto, Y., Bell, G.I. Diabetologia (2000) [Pubmed]
  2. Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Nishimura, M., Naito, S., Yokoi, T. Drug Metab. Pharmacokinet. (2004) [Pubmed]
  3. Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Maglich, J.M., Sluder, A., Guan, X., Shi, Y., McKee, D.D., Carrick, K., Kamdar, K., Willson, T.M., Moore, J.T. Genome Biol. (2001) [Pubmed]
  4. Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Taraviras, S., Mantamadiotis, T., Dong-Si, T., Mincheva, A., Lichter, P., Drewes, T., Ryffel, G.U., Monaghan, A.P., Schütz, G. Biochim. Biophys. Acta (2000) [Pubmed]
  5. Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. Ozeki, T., Takahashi, Y., Nakayama, K., Funayama, M., Nagashima, K., Kodama, T., Kamataki, T. Pharmacogenetics (2003) [Pubmed]
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