Gene Review:
AKR1C4 - aldo-keto reductase family 1, member C4
Homo sapiens
Synonyms:
3-alpha-HSD, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Aldo-keto reductase family 1 member C4, C11, ...
- Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. Ozeki, T., Takahashi, Y., Nakayama, K., Kamataki, T. Arch. Biochem. Biophys. (2002)
- Allopregnanolone serum levels and expression of 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase isoforms in hippocampal and temporal cortex of patients with epilepsy. Stoffel-Wagner, B., Watzka, M., Steckelbroeck, S., Ludwig, M., Clusmann, H., Bidlingmaier, F., Casarosa, E., Luisi, S., Elger, C.E., Beyenburg, S. Epilepsy Res. (2003)
- Reduced protein kinase C activity in a ras-resistant cell line derived from Ki-MSV transformed cells. Kamata, T., Sullivan, N.F., Wooten, M.W. Oncogene (1987)
- Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni. Oppermann, U.C., Maser, E. Eur. J. Biochem. (1996)
- Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study. Lord, S.J., Mack, W.J., Van Den Berg, D., Pike, M.C., Ingles, S.A., Haiman, C.A., Wang, W., Parisky, Y.R., Hodis, H.N., Ursin, G. Breast Cancer Res. (2005)
- 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. Beasley, C.R., Robinson, C., Featherstone, R.L., Varley, J.G., Hardy, C.C., Church, M.K., Holgate, S.T. J. Clin. Invest. (1987)
- Cloning, sequencing, and functional analysis of the 5'-flanking region of the rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase gene. Lin, H.K., Penning, T.M. Cancer Res. (1995)
- Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., Penning, T.M. J. Biol. Chem. (2004)
- Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. Di, Y.P., Harper, R., Zhao, Y., Pahlavan, N., Finkbeiner, W., Wu, R. J. Biol. Chem. (2003)
- cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. Stolz, A., Hammond, L., Lou, H., Takikawa, H., Ronk, M., Shively, J.E. J. Biol. Chem. (1993)
- Molecular cloning of the crustacean DD4 cDNA encoding a Ca(2+)-binding protein. Endo, H., Persson, P., Watanabe, T. Biochem. Biophys. Res. Commun. (2000)
- Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. Ji, Q., Chang, L., VanDenBerg, D., Stanczyk, F.Z., Stolz, A. Prostate (2003)
- Molecular characterization of two monkey dihydrodiol dehydrogenases. Higaki, Y., Kamiya, T., Usami, N., Shintani, S., Shiraishi, H., Ishikura, S., Yamamoto, I., Hara, A. Drug Metab. Pharmacokinet. (2002)
- Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. Deyashiki, Y., Ogasawara, A., Nakayama, T., Nakanishi, M., Miyabe, Y., Sato, K., Hara, A. Biochem. J. (1994)
- Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. Ozeki, T., Takahashi, Y., Nakayama, K., Funayama, M., Nagashima, K., Kodama, T., Kamataki, T. Pharmacogenetics (2003)
- Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. O'connor, T., Ireland, L.S., Harrison, D.J., Hayes, J.D. Biochem. J. (1999)
- Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S.H., Kloosterboer, H.J., Penning, T.M. J. Pharmacol. Exp. Ther. (2006)
- Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA. Shiraishi, H., Ishikura, S., Matsuura, K., Deyashiki, Y., Ninomiya, M., Sakai, S., Hara, A. Biochem. J. (1998)
- Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. Dufort, I., Labrie, F., Luu-The, V. J. Clin. Endocrinol. Metab. (2001)
- Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol. Atalla, A., Breyer-Pfaff, U., Maser, E. Xenobiotica (2000)
- Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Penning, T.M., Burczynski, M.E., Jez, J.M., Hung, C.F., Lin, H.K., Ma, H., Moore, M., Palackal, N., Ratnam, K. Biochem. J. (2000)
- Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Burczynski, M.E., Harvey, R.G., Penning, T.M. Biochemistry (1998)
- Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. Winters, C.J., Molowa, D.T., Guzelian, P.S. Biochemistry (1990)
- Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein. Matsuura, K., Tamada, Y., Deyashiki, Y., Miyabe, Y., Nakanishi, M., Ohya, I., Hara, A. Biochem. J. (1996)