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Gene Review:

Bbc3 - Bcl-2 binding component 3

Rattus norvegicus

Synonyms: Bcl-2-binding component 3, Puma, p53 up-regulated modulator of apoptosis

Reimertz, C. et al.

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Disease relevance of Bbc3

Overexpression of Bbc3/PUMA was sufficient to trigger apoptosis in SH-SY5Y neuroblastoma cells, and human cells deficient in Bbc3/PUMA showed dramatically reduced apoptosis in response to ER stress [1].

High impact information on Bbc3

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway [1].

Biological context of Bbc3

Our data suggest that the transcriptional induction of Bbc3/PUMA may be sufficient and necessary for ER stress-induced apoptosis [1].

Associations of Bbc3 with chemical compounds

Microarray analysis of gene expression changes during tunicamycin-induced apoptosis revealed that the Bcl-2 homology domain 3-only family member, Bcl-2 binding component 3/p53 upregulated modulator of apoptosis (Bbc3/PUMA), was the most strongly induced pro-apoptotic gene [1].

References

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz, C., Kögel, D., Rami, A., Chittenden, T., Prehn, J.H. J. Cell Biol. (2003) [Pubmed]

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