Gene Review:
Bbc3 - BCL2 binding component 3
Mus musculus
Synonyms:
Bcl-2-binding component 3, PUMA, PUMA/JFY1, Puma, p53 up-regulated modulator of apoptosis
- PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress. Nickson, P., Toth, A., Erhardt, P. Cardiovasc. Res. (2007)
- Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Toth, A., Jeffers, J.R., Nickson, P., Min, J.Y., Morgan, J.P., Zambetti, G.P., Erhardt, P. Am. J. Physiol. Heart Circ. Physiol. (2006)
- FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. You, H., Pellegrini, M., Tsuchihara, K., Yamamoto, K., Hacker, G., Erlacher, M., Villunger, A., Mak, T.W. J. Exp. Med. (2006)
- Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. Erlacher, M., Labi, V., Manzl, C., B??ck, G., Tzankov, A., H??cker, G., Michalak, E., Strasser, A., Villunger, A. J. Exp. Med. (2006)
- The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. Besirli, C.G., Wagner, E.F., Johnson, E.M. J. Cell Biol. (2005)
- BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Erlacher, M., Michalak, E.M., Kelly, P.N., Labi, V., Niederegger, H., Coultas, L., Adams, J.M., Strasser, A., Villunger, A. Blood (2005)
- The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Bauer, A., Villunger, A., Labi, V., Fischer, S.F., Strasser, A., Wagner, H., Schmid, R.M., Häcker, G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Maclean, K.H., Keller, U.B., Rodriguez-Galindo, C., Nilsson, J.A., Cleveland, J.L. Mol. Cell. Biol. (2003)
- Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite. Wong, H.K., Fricker, M., Wyttenbach, A., Villunger, A., Michalak, E.M., Strasser, A., Tolkovsky, A.M. Mol. Cell. Biol. (2005)
- BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. Akhtar, R.S., Geng, Y., Klocke, B.J., Latham, C.B., Villunger, A., Michalak, E.M., Strasser, A., Carroll, S.L., Roth, K.A. J. Neurosci. (2006)
- Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Han, J., Flemington, C., Houghton, A.B., Gu, Z., Zambetti, G.P., Lutz, R.J., Zhu, L., Chittenden, T. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Kuroda, J., Puthalakath, H., Cragg, M.S., Kelly, P.N., Bouillet, P., Huang, D.C., Kimura, S., Ottmann, O.G., Druker, B.J., Villunger, A., Roberts, A.W., Strasser, A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Jeffers, J.R., Parganas, E., Lee, Y., Yang, C., Wang, J., Brennan, J., MacLean, K.H., Han, J., Chittenden, T., Ihle, J.N., McKinnon, P.J., Cleveland, J.L., Zambetti, G.P. Cancer Cell (2003)